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Etacrynic acid
go.drugbank.com/drugs/DB00903ApprovedInvestigationalA compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. … This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Products: Edecrin Tab 50mgChlortetracycline
go.drugbank.com/drugs/DB09093ApprovedVet approvedWithdrawnHe discovered that this antibiotic was the product of an actinomycete strain he cultured and obtained from a soil sample from a field in Missouri. … Chlortetracycline is a _tetracycline_ antibiotic, and historically the first member of this class to be identified.
Categories: Alimentary Tract and Metabolism, Antiinfectives and Antiseptics for Local Oral TreatmentColistin
go.drugbank.com/drugs/DB00803ApprovedInvestigationalCyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. … Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Categories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and ProteinsTechnetium Tc-99m mebrofenin
go.drugbank.com/drugs/DB09137ApprovedWithdrawnMore specifically, mebrofenin is taken up into hepatocytes through the action of OATP1B1 and OATP1B3 transporters. … Liver and gallbladder imaging is enabled through attachment to mebrofenin as this molecule has high hepatic uptake and fast biliary excretion, resulting in improved hepatic imaging.
Categories: Indicators and Reagents, Amino Acids, Peptides, and ProteinsQuaternium-15
go.drugbank.com/drugs/DB14198ApprovedIt is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin. … Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics.
Darvadstrocel
go.drugbank.com/drugs/DB16581ApprovedInvestigationalWithdrawnDarvadstrocel is a suspension of expanded human allogeneic adipose-derived mesenchymal stem cells extracted from the subdermal adipose tissue of healthy donors via liposuction. … Perianal fistula is a common manifestation of Crohn’s disease and is often difficult to manage, as it may be associated with complex presentations and symptoms.
Categories: Antineoplastic and Immunomodulating AgentsGivosiran
go.drugbank.com/drugs/DB15066Approved[L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder … [A187991] Givosiran is the second-ever FDA-approved member of the siRNA drug class (the first being [patisiran]), a new class of drugs promising an important and exciting step forward in the treatment
Categories: Alimentary Tract and Metabolism, Various Alimentary Tract and Metabolism ProductsDefactinib
go.drugbank.com/drugs/DB12282ApprovedInvestigational[L53208,A273943] Defactinib was approved by the US FDA in May 2025 in a co-package alongside [avutometinib] (called Avmapki Fakzynja) for the treatment of recurrent KRAS-mutated low-grade serous ovarian … [L53198,L53208] FAK is important for the integrin-mediated activation of several downstream signal transduction pathways, including those involving RAS/MEK/ERK and PI3K/Akt, and its upregulation is a key
Thiabendazole
go.drugbank.com/drugs/DB00730ApprovedVet approvedWithdrawn(From Smith and Reynard, Textbook of Pharmacology, 1992, p919) … It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential.
Categories: Imidazole and Triazole Derivatives, Antiparasitic Products, Insecticides and RepellentsHead Injury
go.drugbank.com/conditions/DBCOND0028168Drugs: CerebrolysinSynonyms: Unspecified injury of face and head