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Somatostatin
go.drugbank.com/drugs/DB09099ApprovedInvestigationalWithdrawnThe actions of somatostatin are mediated via signalling pathways of G protein-coupled somatostatin receptors. … [DB00104] is a long-acting analogue of somatostatin that inhibits the release of a number of hormones, and is clinically used to relieve symptoms of uncommon gastroenteropancreatic endocrine tumours, as
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: SOMATOSAN 3 MG IV INFUZYON ICIN 1 AMPUL, STILAMIN 3000 FOR INJECTION 3 mg/ampouleGonadorelin
go.drugbank.com/drugs/DB00644ApprovedInvestigationalVet approvedIt is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary.
Mixtures: Relisorm 100 for Inj.-pws Liq-kit Sc IVProducts: LH-RH FERRING 0,1 MG/ML IV ENJEKSIYONLUK COZELTI ICEREN AMPUL, 1 ADET, Kryptocur 0,2 mg/0,1 ml - nasale SprühlösungTigecycline
go.drugbank.com/drugs/DB00560ApprovedInvestigationalFood and Drug Administration (FDA) on June 17, 2005. … Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil.
Synonyms: (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamideProducts: TIGECLIN® 50 MG VIAL, GECLIX® 50 MG POLVOSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnThe SVR12 was 83% (29/35) in treatment-naïve patients and 86% (19/22) in relapsing patients. … The overall SVR12 was 88% (44/50) in treatment-naïve patients with cirrhosis [L852].
Categories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 SubstratesProducts: OLYSIO 150 MG KAPSUL ,KAPSUL, 28 ADETCarmustine
go.drugbank.com/drugs/DB00262ApprovedInvestigational(From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). … A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: N,N'-Bis(2-chloroethyl)-N-nitrosoureaDaptomycin
go.drugbank.com/drugs/DB00080ApprovedInvestigational[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal … Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA
Categories: P-glycoprotein substratesProducts: CUBICIN 350 MG ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON, 30 ADET, CUBICIN 500 MG ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON, 30 ADETPantoprazole
go.drugbank.com/drugs/DB00213ApprovedInvestigationalPantoprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … As the binding of pantoprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, pantoprazole's duration of antisecretory effect persists
Mixtures: OCAM® DUO.Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesHyaluronidase
go.drugbank.com/drugs/DB14740ApprovedInvestigational[A199047] Hyaluronidase was first used in prescription products in the United States on 5 May 2004.[L13338] … [A199026] Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue.
Products: Wydase Injection Liq 150 Units/ml, HYLASE® DESSAU 150 IUSodium oxybate
go.drugbank.com/drugs/DB09072ApprovedInvestigational[A18723] For safety reasons, sodium oxybate is a controlled substance only available through a restricted program in approved countries. … [L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter [A251445] and a metabolite of the inhibitory neurotransmitter GABA.
Products: Natriumoxybat Kalceks 500 mg/ml Lösung zum Einnehmen, Natriumoxybat neuraxpharm 500 mg/ml Lösung zum EinnehmenTemazepam
go.drugbank.com/drugs/DB00231ApprovedTemazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal … In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: Temazepam-15, TEMAZEP - CT 10 MG KAPSELN