Gonadorelin is a synthetic GnRH used to test the function of gonadotropes and the pituitary. Gonadorelin is another name for gonadotropin-releasing hormone (GnRH).
- Mechanism
- Curator reviewed
Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
- Primary indication
- For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.Curator reviewed · 1 structured indication
- First approval
- Canada, 2010
- Also known as
- GnRH · Gonadotropin-releasing hormone · Luteinizing Hormone-Releasing Factor
- Code names
- Abbott 41070 · AY 24031 · Hoe 471 · RU 19847
- Brand names
Resolves to
What you can answer from here — as of August 31, 2026
Which drugs share a target with Gonadorelin, and which of those have an active Phase 3 trial?
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