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Ticlopidine
go.drugbank.com/drugs/DB00208ApprovedIt is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. … Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsProducts: TICLID 250 MG TABLET, 30 ADET, TICLOCARD 250 MG FILM KAPLI TABLET, 30 ADETHydrocortisone succinate
go.drugbank.com/drugs/DB14545ApprovedInvestigationalCategories: 17-Hydroxycorticosteroids, Cytochrome P-450 SubstratesProducts: SOLU-CORTEF® 100 MG POLVO PARA INYECCION, SOLU-CORTEF FOR INJECTION 100 mg/vialClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawnClofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. … It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids.
Categories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 CYP2C8 InhibitorsProducts: Fazim 50 mg Capsule, CLOFZIMIN® 100 MGThalidomide
go.drugbank.com/drugs/DB01041ApprovedInvestigationalWithdrawnA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. … It has been reintroduced and used for a number of inflammatory disorders and cancers.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: 3-Phthalimidoglutarimide, (+-)-N-(2,6-dioxo-3-Piperidyl)phthalimideTafamidis
go.drugbank.com/drugs/DB11644ApprovedInvestigational[A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]
Synonyms: 2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid, 6-BENZOXAZOLECARBOXYLIC ACID, 2-(3,5-DICHLOROPHENYL)-Categories: Heterocyclic Compounds, 2-RingLicaminlimab
go.drugbank.com/drugs/DB18936InvestigationalLicaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease).
Synonyms: sapiens IGKV1-5*03 (79.2%) -(IGHD) -IGKJ2*02 (77., immunoglobulin scFv, anti-[Homo sapiens TNF (tumor necrosis factor, TNFSF2, DIF, TNF-alpha)], humanized monoclonal antibody single chain; IG scFv humanized single chain (V-KAPPA-VH) (1-254) [V-KAPPA (HomoAfatinib
go.drugbank.com/drugs/DB08916ApprovedInvestigationalAfatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. … For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations as detected
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: GIOTRIF® 50 MG, GIOTRIF® 30 MGErgoloid mesylate
go.drugbank.com/drugs/DB01049Approved[A32914] The mixture of ergoloid mesylate was first developed by Novartis and FDA approved on November 5, 1953, but this specific formulation is now discontinued. … [T90] The derivatives of this fungus are identified to be about 350 different substances from which the components of the ergoloid mesylate mixture are composed of the dihydrogenated ergot alkaloid derivatives
Mixtures: TOTERJİN DAMLA, 50 CCCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNevirapine
go.drugbank.com/drugs/DB00238ApprovedInvestigationalA potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS.
Mixtures: TRIVIRO LNS® LAMIVUDINA 150 MG NEVIRAPINA 200 MG ESTAVUDINA 40 MG, LAMIVUDINA 150 MG + ZIDOVUDINA 300 MG + NEVIRAPINA 200 MG TABLETAS CUBIERTASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersFlutamide
go.drugbank.com/drugs/DB00499ApprovedInvestigationalAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
Synonyms: α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide, 4'-nitro-3'-trifluoromethylisobutyranilideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates