Hydrocortisone succinate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Hydrocortisone succinate is a corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.

Brand Names
Solu-cortef
Generic Name
Hydrocortisone succinate
DrugBank Accession Number
DB14545
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 462.539
Monoisotopic: 462.225368055
Chemical Formula
C25H34O8
Synonyms
  • Cortisol 21-(hydrogen succinate)
  • Cortisol succinate
  • Hydrocortisone hemisuccinate anhydrous
  • Hydrocortisone hydrogen succinate
  • Hydrocortisone succinate
  • Hydroxycortisone succinate

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbametapirThe serum concentration of Hydrocortisone succinate can be increased when it is combined with Abametapir.
AbataceptThe risk or severity of adverse effects can be increased when Abatacept is combined with Hydrocortisone succinate.
AbemaciclibThe metabolism of Abemaciclib can be increased when combined with Hydrocortisone succinate.
AcalabrutinibThe metabolism of Acalabrutinib can be increased when combined with Hydrocortisone succinate.
AcarboseThe risk or severity of hyperglycemia can be increased when Hydrocortisone succinate is combined with Acarbose.
AceclofenacThe risk or severity of gastrointestinal irritation can be increased when Hydrocortisone succinate is combined with Aceclofenac.
AcemetacinThe risk or severity of gastrointestinal irritation can be increased when Hydrocortisone succinate is combined with Acemetacin.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Hydrocortisone succinate.
AcetohexamideThe risk or severity of hyperglycemia can be increased when Hydrocortisone succinate is combined with Acetohexamide.
AcetyldigitoxinThe risk or severity of adverse effects can be increased when Hydrocortisone succinate is combined with Acetyldigitoxin.
Interactions
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Food Interactions
No interactions found.

Products

Products
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Product Ingredients
IngredientUNIICASInChI Key
Hydrocortisone sodium succinate50LQB69S1Z125-04-2HHZQLQREDATOBM-CODXZCKSSA-M
Hydrocortisone succinate monohydrateLIU00Z1Z8483784-20-7AFLWPAGYTPJSEY-CODXZCKSSA-N
Active Moieties
NameKindUNIICASInChI Key
HydrocortisoneunknownWI4X0X7BPJ50-23-7JYGXADMDTFJGBT-VWUMJDOOSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Solu-cortefInjection, powder, for solution100 mg/2mLIntramuscular; IntravascularCardinal Health1955-04-272015-02-28US flag
Solu-cortefInjection, powder, for solution500 mg/4mLIntramuscular; IntravascularPharmacia & Upjohn Inc1980-04-272014-07-01US flag
Solu-cortefInjection, powder, for solution250 mg/2mLIntramuscular; IntravenousHF Acquisition Co. LLC, DBA HealthFirst2018-09-03Not applicableUS flag
Solu-CortefInjection, powder, for solution500 mg/4mLIntramuscular; IntravenousPharmacia & Upjohn Company LLC1955-04-27Not applicableUS flag
Solu-CortefInjection, powder, for solution100 mg/2mLIntramuscular; IntravenousPhysicians Total Care, Inc.1955-04-272013-06-01US flag
Solu-CortefInjection, powder, for solution100 mg/2mLIntramuscular; IntravenousPharmacia & Upjohn Company LLC1955-04-27Not applicableUS flag
Solu-cortefInjection, powder, for solution1000 mg/8mLIntramuscular; IntravascularPharmacia & Upjohn Inc1980-04-272014-05-01US flag
Solu-cortefInjection, powder, for solution100 mg/2mLIntramuscular; IntravenousHF Acquisition Co. LLC, DBA HealthFirst2018-09-03Not applicableUS flag
Solu-cortefInjection, powder, for solution250 mg/2mLIntramuscular; IntravascularPharmacia & Upjohn Inc1980-04-272014-10-01US flag
Solu-CortefInjection, powder, for solution250 mg/2mLIntramuscular; IntravenousPharmacia & Upjohn Company LLC1955-04-27Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
A-hydrocortInjection, powder, lyophilized, for solution100 mg/2mLIntramuscular; IntravenousHospira, Inc.2006-12-142010-07-01US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
IHV1VP592V
CAS number
2203-97-6
InChI Key
VWQWXZAWFPZJDA-CGVGKPPMSA-N
InChI
InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1
IUPAC Name
4-{2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-4-oxobutanoic acid
SMILES
[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

References

General References
Not Available
KEGG Drug
D01442
ChemSpider
15760
BindingDB
50016931
RxNav
21651
ChEBI
31677
ChEMBL
CHEMBL977
ZINC
ZINC000004097472
Wikipedia
Hydrocortisone_hemisuccinate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentSeptic Shock2
4CompletedTreatmentShock1
4Unknown StatusTreatmentUlcerative Colitis1
4Unknown StatusTreatmentUlcerative Colitis, Unspecified1
3Active Not RecruitingTreatmentAdult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentB Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Ph-Like Acute Lymphoblastic Leukemia / Testicular Leukemia1
3Active Not RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19) / Hypoxia1
3CompletedSupportive CareLeukemias / Malignant Lymphomas / Toxicity, Cardiac1
3CompletedSupportive CareSeptic1
3CompletedTreatmentLeukemias / Malignant Lymphomas1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous100 mg/2mL
Injection, powder, for solution
InjectionIntramuscular; Intravenous
Powder100 mg/1vial
Injection, powder, lyophilized, for solutionIntravenous100 mg
Injection, powder, for solutionIntramuscular; Intravascular100 mg/2mL
Injection, powder, for solutionIntramuscular; Intravascular1000 mg/8mL
Injection, powder, for solutionIntramuscular; Intravascular250 mg/2mL
Injection, powder, for solutionIntramuscular; Intravascular500 mg/4mL
Injection, powder, for solutionIntramuscular; Intravenous100 mg/2mL
Injection, powder, for solutionIntramuscular; Intravenous1000 mg/8mL
Injection, powder, for solutionIntramuscular; Intravenous250 mg/2mL
Injection, powder, for solutionIntramuscular; Intravenous500 mg/4mL
Injection, powder, for solutionIntramuscular; Intravenous100 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0653 mg/mLALOGPS
logP2.17ALOGPS
logP1.54ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)3.66ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area138.2 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity117.44 m3·mol-1ChemAxon
Polarizability48.68 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Joellenbeck L, Qian Z, Zarba A, Groopman JD: Urinary 6 beta-hydroxycortisol/cortisol ratios measured by high-performance liquid chromatography for use as a biomarker for the human cytochrome P-450 3A4. Cancer Epidemiol Biomarkers Prev. 1992 Nov-Dec;1(7):567-72. [Article]
  2. Litt J. (2016). Litt's Drug eruption & reaction manual (22nd ed.). CRC Press LLc.
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Bauersachs J, Christ M, Ertl G, Michaelis UR, Fisslthaler B, Busse R, Fleming I: Cytochrome P450 2C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol. Cardiovasc Res. 2002 Jun;54(3):669-75. [Article]
  2. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
Gene Name
CYP11B1
Uniprot ID
P15538
Uniprot Name
Cytochrome P450 11B1, mitochondrial
Molecular Weight
57572.44 Da
References
  1. Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM: Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Gene Name
CYP11B2
Uniprot ID
P19099
Uniprot Name
Cytochrome P450 11B2, mitochondrial
Molecular Weight
57559.62 Da
References
  1. Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM: Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. [Article]

Drug created on July 12, 2018 21:25 / Updated on May 07, 2021 21:40