Hydrocortisone succinate

DB14545ApprovedInvestigationalSmall moleculeCorticosteroids

Hydrocortisone succinate is a corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. A medication used to treat inflammation, immune reactions, hormone conditions, and abnormal cell growth.

Mechanism: Pharmacologically active on Glucocorticoid receptor
Curator reviewed
Formula / weight: C₂₅H₃₄O₈ · 462.539 g/mol (avg)
First approval: Canada, 2003 · United States, 1955
Also known as: Cortisol succinate · Hydrocortisone hydrogen succinate · Hydroxycortisone succinate
Brand names: Solu-cortef

Resolves to

Compound

UNIIIHV1VP592VCAS2203-97-6ChEMBLCHEMBL977ChEBI31677KEGGD01442

Clinical / RWD

RxNorm21651

Structure

InChIKeyVWQWXZAWFPZJDA-CGVGKPPMSA-NSMILES[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Targets

P04150NR3C1

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1,068Drug interactionsStructured to mechanism, not free text

52Clinical trialsPhase, status and sponsor resolved per trial

48Structured indicationsCondition, population, route and combination as fields, not prose

45Marketed productsAcross 8 countries and 24 labellers

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Hydrocortisone succinate, and which of those have an active Phase 3 trial?

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