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Glutethimide
go.drugbank.com/drugs/DB01437ApprovedIllicitIts use has been largely superseded by other drugs.
Goserelin
go.drugbank.com/drugs/DB00014ApprovedInvestigationalWhen the medication is stopped, hormone levels return to normal. … In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state.
Relatlimab
go.drugbank.com/drugs/DB14851ApprovedInvestigational[L41265,L41300] It was the first anti-LAG-3 antibody to demonstrate benefit in a Phase 3 study, as well as the first to receive FDA approval. … efficacy when used alone, drugs like relatlimab have been trialed in combination with other checkpoint inhibitors - for example, PD-1 inhibitors like [nivolumab] or CTLA-4 inhibitors like [ipilimumab] - to
CZEN 002
go.drugbank.com/drugs/DB05479ExperimentalThe antimicrobial activity of CZEN-002 is unique in that it does not depend on direct damage to the microbial membrane. … It appears that CZEN-002 works on a receptor in yeast that has yet to be identified.
Deutivacaftor
go.drugbank.com/drugs/DB15141ApprovedInvestigationalIt is used alongside CFTR correctors to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis. … [L52275,A179677] Deutivacaftor was first approved by the US FDA in December 2024 in combination with two CFTR correctors - [tezacaftor] and [vanzacaftor] - for the treatment of patients with responsive
AC3056
go.drugbank.com/drugs/DB05230ExperimentalAC3056 is a non-peptide antioxidant that acts as an inhibitor of vascular cell adhesion molecule expression originally developed by Aventis Pharmaceuticals. … It as since been acquired by Amylin Pharmaceuticals and has completed phase I trials.
Ketazolam
go.drugbank.com/drugs/DB01587ApprovedWithdrawnKetazolam is not approved in Canada or America.
AT2220
go.drugbank.com/drugs/DB05200InvestigationalGAA to the lysosome, where it can perform its normal function. … AT2220 is an experimental, oral therapy for the treatment of Pompe disease and belongs to a class of molecules known as pharmacological chaperones.