Glutethimide

DB01437ApprovedIllicitSmall molecule

Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs.

Mechanism: Glutethimide seems to be a GABA agonist which helps induce sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of codeine (higher than the average 5 - 10%) to morphine. This combination of effects enhances sedation.
Curator reviewed
Primary indication: For the treatment of insomnia.Curator reviewed
Formula / weight: C₁₃H₁₅NO₂ · 217.2637 g/mol (avg)

Resolves to

Compound

UNIIC8I4BVN78ECAS77-21-4ChEMBLCHEMBL1102ChEBI5439PubChem3487KEGGD00532

Clinical / RWD

RxNorm4903ATCN05CE01PharmGKBPA164749505

Structure

InChIKeyJMBQKKAJIKAWKF-UHFFFAOYSA-NSMILESCCC1(CCC(=O)NC1=O)C1=CC=CC=C1

Targets

P14867GABRA1P10635CYP2D6

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

682Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 8 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Glutethimide, and which of those have an active Phase 3 trial?

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