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Displaying results 311 - 320 of 10000 in total
  1. Drug

    Quinidine

    go.drugbank.com/drugs/DB00908
    Approved

    Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species. … This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InducersSynonyms: (R)-(6-Methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol, α-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
  2. Drug

    Thymidine

    go.drugbank.com/drugs/DB04485
    ApprovedInvestigational

    toxicity of established anti-metabolite chemotherapeutic agents, such as 5-Fluorouracil (FU), Methotrexate (MTX), and Cytosine arabinoside (ara-C). … Thymidine is a naturally occurring deoxyribonucleoside that is a crucial component of the DNA salvage pathway and a building block for DNA synthesis.

    Synonyms: MT-1621 COMPONENT 2'-DEOXYTHYMIDINE, 1-(2-Deoxy-?-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedioneCategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Rosiglitazone

    go.drugbank.com/drugs/DB00412
    ApprovedInvestigational

    This is the subject of a clinical trial currently underway. … Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione, (RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion
  4. Drug

    Danicopan

    go.drugbank.com/drugs/DB15401
    ApprovedInvestigational

    with C5 inhibitors. … [A263501] Standard therapy for PNH involves the use of complement C5 inhibitors (e.g.

    Categories: P-glycoprotein inhibitors, Complement Factor D InhibitorSynonyms: (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide, (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidine-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridine-2-yl)-4-fluoropyrrolidine-2-carboxamide
  5. Drug

    Ataluren

    go.drugbank.com/drugs/DB05016
    ApprovedWithdrawn

    Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk. … Ataluren is a novel, orally administered drug that targets nonsense mutations.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
  6. Drug

    Dextran

    go.drugbank.com/drugs/DB09255
    ApprovedInvestigationalVet approved

    Dextran 75 is a complex branched glucan with an average molecular weight 75000 Daltons. … [T121] Dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection.

    Salts: Dextran 75, Dextran 70Mixtures: LİFE-EXTEND 60 MG/ML DEKSTRAN 70 + 75 MG/ML SODYUM KLORÜR I.V. İNFÜZYON İÇİN ÇÖZELTİ, 250 ML, SETSİZ, TEARS NATURALE II 1 MG/ML + 3 MG/ML GÖZ DAMLASI
  7. Drug

    2'-deoxy-5-(hydroxymethyl)uridine 5'-(dihydrogen phosphate)

    go.drugbank.com/drugs/DB03846
    Experimental

    Synonyms: 5-hydroxymethyluridine-2'-deoxy-5'-monophosphate, 2'-deoxy-5-(hydroxymethyl)uridine 5'-(dihydrogen phosphate)
  8. Drug

    Tipiracil

    go.drugbank.com/drugs/DB09343
    ApprovedInvestigational

    Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102.

    Synonyms: 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione, 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dioneMixtures: LONSURF FILM-COATED TABLET 15 MG/6.14 MG, LONSURF FILM-COATED TABLET 15 MG/6.14 MG
  9. Drug

    Daprodustat

    go.drugbank.com/drugs/DB11682
    ApprovedInvestigational

    [A254157] A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, daprodustat was non-inferior to erythropoiesis-stimulating agents regarding the change in the hemoglobin … Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.

    Synonyms: Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)-Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
  10. Drug

    6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL

    go.drugbank.com/drugs/DB07820
    Experimental

    Synonyms: 6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL