This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Daprodustat
DrugBank Accession Number
DB11682
Background

Daprodustat has been used in trials studying the other, treatment, and basic science of Anaemia, Wound Healing, Tendon Injuries, Surgical Procedures, and Vascular Disease, Peripheral.

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 393.44
Monoisotopic: 393.189985601
Chemical Formula
C19H27N3O6
Synonyms
  • Daprodustat
External IDs
  • GSK-1278863
  • GSK1278863

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

ATC Codes
B03XA07 — Daprodustat
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
N-acyl-alpha amino acids
Alternative Parents
Barbituric acid derivatives / N-acyl ureas / Diazinanes / 1,3-dicarbonyl compounds / Dicarboximides / Secondary carboxylic acid amides / Monocarboxylic acids and derivatives / Carboxylic acids / Azacyclic compounds / Organopnictogen compounds
show 3 more
Substituents
1,3-diazinane / 1,3-dicarbonyl compound / Aliphatic heteromonocyclic compound / Azacycle / Barbiturate / Carbonic acid derivative / Carbonyl group / Carboxamide group / Carboxylic acid / Dicarboximide
show 16 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
JVR38ZM64B
CAS number
960539-70-2
InChI Key
RUEYEZADQJCKGV-UHFFFAOYSA-N
InChI
InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
IUPAC Name
2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinan-5-yl)formamido]acetic acid
SMILES
OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O

References

General References
Not Available
PubChem Compound
91617630
PubChem Substance
347828049
ChemSpider
33427356
ChEMBL
CHEMBL3544988
ZINC
ZINC000231226004
Wikipedia
Daprodustat

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAllergic Bronchopulmonary Aspergillosis / Anemia1
3CompletedTreatmentAnemia7
2Active Not RecruitingTreatmentAnemia1
2CompletedBasic SciencePeripheral Vascular Disease Patient1
2CompletedTreatmentAnemia7
2CompletedTreatmentSurgical Procedures1
2TerminatedTreatmentAnemia2
1CompletedBasic ScienceAnemia1
1CompletedOtherAnemia2
1CompletedTreatmentAnemia6

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.345 mg/mLALOGPS
logP1.48ALOGPS
logP1.4ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)0.35ChemAxon
pKa (Strongest Basic)-9.1ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area124.09 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity96.89 m3·mol-1ChemAxon
Polarizability40.18 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at October 20, 2016 20:39 / Updated at February 21, 2021 18:53