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Revumenib
go.drugbank.com/drugs/DB18515ApprovedInvestigationalMenin is a scaffold protein that interacts with both the wild-type and rearranged KMT2A, which is crucial for KMT2A activity and the maintenance of _HOXA_ expression and leukemogenesis. … [L51888] In October of 20225, it was approved for myeloid leukemia patients with nucleophosmin 1 (NPM1) mutations. [L54376]
Synonyms: Benzamide, n-ethyl-2-((4-(7-((trans-4-((ethylsulfonyl)amino)cyclohexyl)methyl)-2,7-diazaspiro(3.5)non-2-yl)-5-pyrimidinyl)oxy)-5-fluoro-n-(1-methylethyl)-Categories: MATE 1 Inhibitors, MATE 1 SubstratesDabigatran
go.drugbank.com/drugs/DB14726ApprovedInvestigationalDabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate.
Categories: Factor Xa Inhibitors, Direct factor Xa inhibitorsOrmeloxifene
go.drugbank.com/drugs/DB13310ExperimentalOrmeloxifene is a third-generation selective estrogen receptor (ER) modulator. … [A251450,A251460] Ormeloxifene is marketed in India as a racemic mixture of the l- (levormeloxifene) and d-isomers (d-ormeloxifene) of _trans_-ormeloxifene.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingPearl (hyriopsis cumingii)
go.drugbank.com/drugs/DB14249InvestigationalPearl (hyriopsis cumingii) is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: Ma Ying Long HemorrhoidalDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalA prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … [A234379] Agents acting on the PD-1 pathway, such as [nivolumab] and [pembrolizumab], facilitate endogenous immune-mediated anti-tumor activity and may therefore be used to treat a wide variety of cancers
Synonyms: Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), disulfide with humanized clone ABT1 kappa-chain, dimerCategories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsOmbitasvir
go.drugbank.com/drugs/DB09296ApprovedInvestigationalIn a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) recommend Ombitasvir as a first line … Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Categories: P-glycoprotein substrates, Treatments for Hepatitis CSynonyms: dimethyl ([(2S,5S)-1-(4-tert-butylphenyl)pyrrolidine-2,5-diyl]bis{(4,1-phenylene)carbamoyl(2S)pyrrolidine-2,1-diyl[(2S)-3-methyl-1-oxobutane-1,2-diyl]})biscarbamatePegcetacoplan
go.drugbank.com/drugs/DB16694ApprovedInvestigationalPegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria (PNH). … [A235000,A235005] Pegcetacoplan was developed out of a need for an inhibitor of complement mediated hemolysis further upstream of C5.
Products: EMPAVELI® 54 MG/ML SOLUCIÓN INYECTABLE2-deoxyglucose
go.drugbank.com/drugs/DB08831InvestigationalBy using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. … 2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel).
Synonyms: 2-deoxy-D-glucose, 2-Deoxy-D-arabino-hexoseEzatiostat
go.drugbank.com/drugs/DB05460InvestigationalMany conditions are characterized by depleted bone marrow, including myelodysplastic syndrome (MDS), a form of pre-leukemia in which the bone marrow produces insufficient levels of one or more of the 3 … It might also be relevant as an adjunct therapy since a reduction in blood cell levels is also a common, toxic effect of many standard chemotherapeutic drugs.
Synonyms: gamma-Glutamyl-S-(benzyl)-cysteinyl-R(-)-phenylglycine diethyl esterLecithin, soybean
go.drugbank.com/drugs/DB14161InvestigationalLecithin is a component of the cell membrane and commercially extracted from soybeans and egg yolk. … A complex mixture of phospholipids; glycolipids; and triglycerides; with substantial amounts of phosphatidylcholines; phosphatidylethanolamines; and phosphatidylinositols, which are sometimes loosely termed
Mixtures: GNC PP AA FormulaProducts: Essentiale Forte N, Lipopharm® Capsule 300mg