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Metoclopramide
go.drugbank.com/drugs/DB01233ApprovedInvestigational[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). … It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.
Categories: Drugs for Functional Gastrointestinal Disorders, Dopamine D2 Receptor AntagonistsProducts: Mar-metoclopramide, PP-METOCLOPRAMIDE TABLETOfatumumab
go.drugbank.com/drugs/DB06650ApprovedInvestigationalIn February 2020, FDA and EMA approved Supplemental Biologics License Application (sBLA) and Marketing Authorization Application (MAA), respectively, for ofatumumab for the treatment of RMS in adults. … [A6921] Ofatumumab is available for intravenous administration and is marketed as Arzerra.
Products: KESIMPTA SOLUTION FOR INJECTION IN PRE-FILLED PEN 20MG/0.4ML, Bonspri 20mg/0.4mL Solution for Injection in Pre-filled syringeCabazitaxel
go.drugbank.com/drugs/DB06772ApprovedInvestigational[A7056] Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more readily penetrate the blood–brain barrier compared to other taxanes like [paclitaxel] and [docetaxel].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: JEVTANA 60mg CONCENTRATE AND SOLVENT FOR SOLUTION FOR INFUSION, JEVTANA (CONCENTRATE AND SOLVENT FOR SOLUTION FOR INFUSION)Polatuzumab vedotin
go.drugbank.com/drugs/DB12240ApprovedInvestigational[L6658] The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable linker called maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl … Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: POLIVY POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 140MG, POLIVY POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 30MGAzacitidine
go.drugbank.com/drugs/DB00928ApprovedInvestigational[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. … [A1407,A1410,A1411,A1416,A1417] In May 2004, the FDA approved the use of azacitidine administered subcutaneously for the treatment of MDS of all French-American-British (FAB) subtypes.
Products: Azacitidine For, Vidaza powder for suspension for injection 100mg/vialRanibizumab
go.drugbank.com/drugs/DB01270ApprovedInvestigationalIn order to improve drug delivery to the target organ, ranibizumab is available for intravitreal use. … ranibizumab first began after [bevacizumab], another anti-VEGF anticancer drug, was discovered to inhibit neovascularization and used in the off-label treatment of neovascular age-related macular degeneration for
Products: Lucentis 10mg/ml Solution for Injection, ACCENTRIX 10MG/ML SOLUTION FOR INJECTIONPeginterferon alfa-2b
go.drugbank.com/drugs/DB00022ApprovedInvestigational-2b for the treatment of Hepatitis C [A19593]. … Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Categories: Treatments for Hepatitis C, Cytochrome P-450 CYP2C9 InducersProducts: PEG-INTRON CLEARCLICK FOR INJECTION 80 mcg/0.5 ml, PEG-INTRON CLEARCLICK FOR INJECTION 100 mcg/0.5 mlPheniramine
go.drugbank.com/drugs/DB01620ApprovedPheniramine's use as an anti-allergy medication has largely been supplanted by second-generation antihistamines such as [cetirizine] and [loratadine].
Mixtures: Hot Lemon for Colds Powder, Neo Citran - Pulver für ErwachseneCategories: Antihistamines for Systemic Use, Antihistamines for Topical UseRamucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalVEGFR stimulation also mediates downstream signalling required for angiogenesis and is postulated to be heavily involved in cancer progression, making it a highly likely drug target. … Ramucirumab is indicated for us in advanced gastric or gastro-esophageal junction adenocarcinoma as a single agent or in combination with paclitaxel after prior fluoropyrimidine- or platinum-containing
Categories: Vascular Endothelial Growth Factor Receptor 2 Antagonist, VEGF/VEGFR (Vascular Endothelial Growth Factor / -Receptor) inhibitorsProducts: CYRAMZA CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/10ML, CYRAMZA CONCENTRATE FOR SOLUTION FOR INFUSION 500MG/50MLAlglucosidase alfa
go.drugbank.com/drugs/DB01272ApprovedInvestigationalIt is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients. … Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes.
Products: Myozyme Powder for Solution for Injection, (Alglucosidase alfa) 50mg Powder for Solution for Infusion