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Displaying results 321 - 330 of 10000 in total
  1. Drug

    Oxybutynin

    go.drugbank.com/drugs/DB01062
    ApprovedInvestigational

    It is often used as first-line therapy for OAB.[A185990] … efficacy since initial FDA approval in 1975.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsSynonyms: 4-Diethylamino-2-butinyl alpha-cyclohexylmandelat, 4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate
  2. Drug

    Trimebutine

    go.drugbank.com/drugs/DB09089
    ApprovedInvestigational

    Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. … Trimebutine is not a FDA-approved drug, but it is available in Canada and several other international countries.

    Synonyms: 2-Dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoatMixtures: RECBUTIN 120 MG/10 MG SUPOZITUVAR, 10 ADET, LIBERTRIM® SII 100 MG
  3. Drug

    Brivaracetam

    go.drugbank.com/drugs/DB05541
    ApprovedInvestigational

    Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam [A19184]. … It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 [L760].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: BRIVIACT 10 MG FILM KAPLI TABLET ,14 FILM KAPLI TABLET, BRIVIACT 50 MG FILM KAPLI TABLET ,14 FILM KAPLI TABLET
  4. Drug

    Itraconazole

    go.drugbank.com/drugs/DB01167
    ApprovedInvestigational

    While the intravenous formulation of the drug was formerly available, it was discontinued in the US in 2007.[A263232] … [L50051] Itraconazole was first approved in the US in 1992 [L50056] and is available orally.

    Synonyms: (±)-1-SEC-BUTYL-4-(P-(4-(P-(((2R*,4S*)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)-1-PIPERAZINYL)PHENYL)-.DELTA.(SUP 2)-1,2,4-TRIAZOLIN-5-ONE, 3H-1,2,4-TRIAZOL-3-ONE, 4-(4-(4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)-1-PIPERAZINYL)PHENYL)-2,4-DIHYDRO-2-(1-METHYLPROPYL)-Mixtures: ITRACONAZOL 33.3 MG + SECNIDAZOL 166.66 MG CÁPSULA, Ciclopirox 3% / Itraconazole 5% / Urea 20%
  5. Drug

    Albumin human

    go.drugbank.com/drugs/DB00062
    ApprovedInvestigational

    This is a biosimilar drug to existing human serum albumin and was approved for a biological license at both 5% and 25% concentrations by the FDA on June 21, 2018 [L3101]. … Albumin represents approximately 50% of the total protein content in healthy humans [A40060].

    Products: Pulmocis 2 mg Kit für ein radioaktives Arzneimittel, CEALB ALBUMIN %20 50 ML 10 GR
  6. Drug

    Indomethacin

    go.drugbank.com/drugs/DB00328
    ApprovedInvestigational

    NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole … Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and Drug Administration in 1965, [A486] along with other acetic acid derivatives such as [diclofenac]

    Mixtures: INDOBIOTIC GOZ DAMLASI, 5 MLCategories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 2-Ring
  7. Drug

    Niacin

    go.drugbank.com/drugs/DB00627
    ApprovedInvestigationalNutraceutical

    Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.

    Mixtures: Niacin 500 Mg and Inositol, Ni-C-E-LE PlusCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 CYP2E1 Inhibitors
  8. Drug

    Benmelstobart

    go.drugbank.com/drugs/DB17473
    Investigational

    APL 502 is a humanised immunoglobulin G1 (IgG1) monoclonal antibody targeting the programmed cell death-1 ligand-1 (PD-L1).

    Synonyms: gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*01 (78.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, Immunoglobulin G1 [264-alanine], anti-(human programmed death-ligand 1) (human-Mus musculus monoclonal CBT-502 γ1-chain), disulfide with human-Mus musculus monoclonal CBT-502 κ-chain, dimer
  9. Drug

    Abemaciclib

    go.drugbank.com/drugs/DB12001
    ApprovedInvestigational

    It is either given alone in patients who has undergone endocrine therapy and chemotherapy after the metastasis of cancer, or in combination with [DB00947]. … Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity

    Categories: MATE 2 Inhibitors, Heterocyclic Compounds, 2-RingProducts: YULAREB 50 MG FİLM KAPLI TABLET, 28 ADET, YULAREB 100 MG FİLM KAPLI TABLET, 28 ADET
  10. Drug

    Ersodetug

    go.drugbank.com/drugs/DB18182
    Investigational

    Synonyms: gamma2 heavy chain Homo sapiens (1-444) [VH(Homo sapiens IGHV3-20*01 (98.0%) -(IGHD)-IGHJ6*01 (93.8%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG2*02 (100%), G2m23 CH2 M45.1 (CH1, (119-216), hinge 1-12 (217-228), CH2 M45.1 (279) (2