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Displaying results 3381 - 3390 of 10000 in total
  1. Drug

    Nintedanib

    go.drugbank.com/drugs/DB09079
    ApprovedInvestigational

    Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC). … [A185237] As a chemotherapeutic agent for NSCLC, nintedanib, in combination with [Docetaxel], is reserved for patients who have tried and failed first-line chemotherapeutic options.[L8459]

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
  2. Drug

    Olodaterol

    go.drugbank.com/drugs/DB09080
    ApprovedInvestigational

    A once-a-day treatment with a LABA has several advantages over short-acting bronchodilators and twice-daily LABAs including improved convenience and compliance and improved airflow over a 24-hour period … Single doses of olodaterol have been shown to improve forced expiratory volume in 1 sec (FEV1) for 24 h in patients with COPD, allowing once daily dosing.

    Mixtures: SPIOLTO®RESPIMAT®, SPIOLTO®RESPIMAT®Categories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor Agonists
  3. Drug

    Ivabradine

    go.drugbank.com/drugs/DB09083
    ApprovedInvestigational

    Recently a new indication was added to treat symptomatic heart failure from dilated cardiomyopathy for patients 6 months or more in age[Label]. … Ivabradine acts by selectively inhibiting the "funny" channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the

    Mixtures: CARIVALAN 25/5, CARIVALAN 6.25/5Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  4. Drug

    Benzydamine

    go.drugbank.com/drugs/DB09084
    ApprovedInvestigational

    Moreover, unlike aspirin-like NSAIDs which are acids or metabolised to acids, benzydamine is in fact a weak base. … Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties

    Mixtures: KLOROBEN FORT 3 MG/ML+ 2 MG/ML GARGARA, 200 ML, KLOROBEN FORT 3 MG/ML+ 2 MG/ML ORAL SPREY, 40 MLCategories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-Ring
  5. Drug

    Tixocortol

    go.drugbank.com/drugs/DB09091
    ApprovedWithdrawn

    Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. … It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.[L1078]

  6. Drug

    Butyrylthiocholine

    go.drugbank.com/drugs/DB04250
    Experimental

    A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity.

  7. Drug

    Tretazicar

    go.drugbank.com/drugs/DB04253
    Investigational

    Tretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).

    Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Seocalcitol

    go.drugbank.com/drugs/DB04258
    Investigational

    Categories: Vitamin D and Analogues
  9. Drug

    1-Methylcytosine

    go.drugbank.com/drugs/DB04314
    Experimental

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-Methylcytosine, N-Methylcytosine
  10. Drug

    Monastrol

    go.drugbank.com/drugs/DB04331
    Experimental

    Synonyms: (S)-monastrolCategories: Heterocyclic Compounds, 1-Ring