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Troglitazone
go.drugbank.com/drugs/DB00197ApprovedWithdrawnTroglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 Substratesgamma-Tocopherol
go.drugbank.com/drugs/DB15394Experimentalgamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics).
Synonyms: D-gamma-TocopherolCategories: Vitamin E, Compounds used in a research, industrial, or household settingPine needle oil (pinus mugo)
go.drugbank.com/drugs/DB11276ApprovedMajor components of pine needle oil (pinus mugo) include α-Pinene, β-pinene, δ-3-carene, limonene, β-phellandrene, (E)-caryophyllene, and germacrene D. … It is present in aromatherapeutic agents as a massage oil or fragrance and may also be used as a disinfectant, lubricant, sanitizer, antimicrobial, insecticide and organic herbicide.
Cefiderocol
go.drugbank.com/drugs/DB14879ApprovedInvestigationalCefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics. … [A189150] A concern noted in the trial was a 0.3% higher rate of all cause mortality, the cause of which has not been determined.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 2-RingClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawnClofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. … It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: CLOFZIMIN® 100 MGProlgolimab
go.drugbank.com/drugs/DB16740InvestigationalCategories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsHydroquinidine
go.drugbank.com/drugs/DB15300InvestigationalHydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).
Categories: Antiarrhythmics, Class Ia, Antiarrhythmics, Class INilotinib
go.drugbank.com/drugs/DB04868ApprovedInvestigationalNilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). … ), another tyrosine kinase inhibitor used as a first-line treatment for CML.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: TASIGNA® 150 MG CAPSULASFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawnIt exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. … Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-RingProducts: ฟูลแอนซอล 3 มก., FLUANXOL 1 MGTolboxane
go.drugbank.com/drugs/DB19778ExperimentalTolboxane is a small molecule drug. The usage of the INN stem '-oxan(e)' in the name indicates that Tolboxane is a benzodioxane derivative. Tolboxane has a monoisotopic molecular weight of 232.16 Da.