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Clomipramine
go.drugbank.com/drugs/DB01242ApprovedInvestigationalVet approvedThe antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. … Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder).
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: ANAFRANIL® RETARD 75 MG TABLETAS RECUBIERTAS DE LIBERACION PROLONGADAMethylprednisolone
go.drugbank.com/drugs/DB00959ApprovedInvestigationalVet approvedMethylprednisolone is a prednisolone derivative glucocorticoid with higher potency than prednisone. It was first described in the literature in the late 1950s. Methylprednisolone was granted FDA approval on 24 October 1957. In the outbre...
Mixtures: P-Care D80, P-Care D40Categories: P-glycoprotein inducers, P-glycoprotein substratesIcatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigationalIcatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B2 receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times...
Products: ICATIBANT DR. REDDY'SClarithromycin
go.drugbank.com/drugs/DB01211ApprovedInvestigationalClarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with am...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: CLARITHROMYCIN 1A PH 250MG, CLARITHROMYCIN 1A PH 500MGSimvastatin
go.drugbank.com/drugs/DB00641ApprovedInvestigational[A181090,A181093,A181096,A181427,A181475,A181538] Statins are considered a cost-effective treatment option for CVD due to their evidence of reducing all-cause mortality including fatal and non-fatal CVD … [A181087, A181406] Increasing use of the statin class of drugs is largely due to the fact that cardiovascular disease (CVD), which includes heart attack, atherosclerosis, angina, peripheral artery disease
Mixtures: EXOTIB-DUOCategories: P-glycoprotein inhibitors, P-glycoprotein substratesPrazosin
go.drugbank.com/drugs/DB00457ApprovedInvestigationalPrazosin is a drug used to treat hypertension. Prazosin is marketed by Pfizer and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefit...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: CAPSULAS DE 1MG, Nu-prazo Tab 1mgTrimebutine
go.drugbank.com/drugs/DB09089ApprovedInvestigationalTrimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInternational brands: Shuang Di, Ni Wei FuDexamethasone
go.drugbank.com/drugs/DB01234ApprovedInvestigationalVet approvedDexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other condit...
Mixtures: Dex-Moxi PF, DexMoxiKetor PFCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsCoagulation Factor IX (Recombinant)
go.drugbank.com/drugs/DB00100ApprovedRecombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology. It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, and has structural and f...
Products: CONCENTRADO DE FACTOR IX, BENEFIX 1000 IU IV ENJEKSIYONLUK COZELTI ICIN TOZ VE COZUCULoratadine
go.drugbank.com/drugs/DB00455ApprovedInvestigationalLoratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st genera...
Mixtures: LORACERT- P JARABE, Wal Itin DCategories: P-glycoprotein inhibitors, P-glycoprotein substrates