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Larotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalOn April 10, 2025, the FDA granted full drug approval.[L52805] … Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: VITRAKVI 100 MG SERT KAPSÜL, 56 ADET, VITRAKVI®CÁPSULAS DE 100MGRabeprazole
go.drugbank.com/drugs/DB01129ApprovedInvestigationalRabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form.
Mixtures: RABEDIC 10/75 MG MR KAPSÜL, 20 ADET, RABEDIC 10/75 MG MR KAPSÜL, 30 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersDonepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigationalIn 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. … [A182411] Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage
Mixtures: EUTEBROL-DUO, DEMENT COMBİ 10 MG / 15 MG AĞIZDA DAĞILAN TABLET, 7 TABLETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigationalextensively investigated as an immunosuppressive and antitumour agent. … survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic IndexProducts: RAPAMUNE 1.0 MG GRAGEAS, RAPAMUNE 1 MG 100 FILM DRAJEGliclazide
go.drugbank.com/drugs/DB01120ApprovedInvestigationalIt has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of … a sulfonamide group able to release a proton and the presence of one aromatic group.
Mixtures: GLIFOR PLUS 30 MG/850 MG DEĞIŞTIRILMIŞ SALIMLI TABLET, 30 ADET, GLIFOR PLUS 30 MG/850 MG DEĞIŞTIRILMIŞ SALIMLI TABLET, 60 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesCannabidiol
go.drugbank.com/drugs/DB09061ApprovedInvestigationalIt is approved for use as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS). … In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 SubstratesProducts: ANIMOX® 100 MG/ML SOLUCIÓN ORAL, NEVIOT® 100 MG CÁPSULA BLANDATrimipramine
go.drugbank.com/drugs/DB00726ApprovedInvestigationalTricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexProducts: TRIMIPRAMIN-NEURAX 100 MG, TRIMIPRAMIN-NEURAX 50 MGBetamethasone
go.drugbank.com/drugs/DB00443ApprovedInvestigationalVet approvedBetamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. … [A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders.
Mixtures: Enstilar 50 Mikrogramm/g + 0,5 mg/g Schaum zur Anwendung auf der Haut, Soderm 0,5 mg/g + 20 mg/g Lösung zur Anwendung auf der HautCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InducersHuman immunoglobulin G
go.drugbank.com/drugs/DB00028ApprovedInvestigationalIVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. … IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population.
Categories: Immunoglobulin G, Human Immunoglobulin GSynonyms: Human immunoglobulin G, Immunoglobulin G, humanParoxetine
go.drugbank.com/drugs/DB00715ApprovedInvestigationalParoxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. … Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsProducts: Nu-paroxetine, Ag-paroxetine