Trimipramine

DB00726ApprovedInvestigationalSmall moleculeAntidepressive Agents Indicated for DepressionAntidepressive Agents, Tricyclic

Trimipramine is a tricyclic antidepressant used to treat depression. Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.

Chemical structure of Trimipramine
Mechanism
Curator reviewed
Primary indication
For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbanceCurator reviewed · 3 structured indications
Formula / weight
C20H26N2 · 294.4338 g/mol (avg)
First approval
Canada, 2000 · United States, 1990
Also known as
Trimeprimine · Trimeproprimine
Code names
IF 6120 · IL 6001 · RP-7162

Resolves to

Compound
UNII6S082C9NDTCAS739-71-9ChEMBLCHEMBL644ChEBI9738PubChem5584KEGGD00394
Clinical / RWD
RxNorm10834ATCN06AA06PharmGKBPA451791
Structure
InChIKeyZSCDBOWYZJWBIY-UHFFFAOYSA-NSMILESCC(CN(C)C)CN1C2=CC=CC=C2CCC2=CC=CC=C12
Targets
P31645SLC6A4P23975SLC6A2P28223HTR2AP14416DRD2P35367HRH1P28335HTR2CQ01959SLC6A3P08908HTR1A+7 more
Transporters
P08183ABCB1

What you can answer from here — as of September 23, 2026

19Protein targetsEach mapped to UniProt, with action and pharmacological action
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1TransporterSubstrate / inhibitor direction, not just membership
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1,940Drug interactionsStructured to mechanism, not free text
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3Clinical trialsPhase, status and sponsor resolved per trial
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3Structured indicationsCondition, population, route and combination as fields, not prose
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3ContraindicationsEach with its own population and attribute set
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142Marketed productsAcross 5 countries and 18 labellers
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1ATC codeIncluding every combination product, plus 48 drug categories
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41+ReferencesStructured and connected to the statements they support
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