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Displaying results 3611 - 3620 of 10000 in total
  1. Drug

    Remestemcel-L

    go.drugbank.com/drugs/DB13973
    ApprovedInvestigationalWithdrawn

    Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. … Based on its tolerability and safety profile, remestemcel-L is a promising alternative to second-line immunosuppressive agents [A31818].

    Synonyms: Remestemcel-L
  2. Drug

    Oliceridine

    go.drugbank.com/drugs/DB14881
    ApprovedInvestigational

    [A218026, A218031] By acting as a biased agonist, oliceridine provides comparable analgesia compared with traditional opioids such as [morphine] at a comparable or decreased risk of opioid-related adverse … [A218026, A218031, A218036, A218041, A218046] Oliceridine (formerly known as TRV130) is a "biased agonist" at the μ-opioid receptor by preferentially activating the G-protein pathway with minimal receptor

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 奥赛利定
  3. Drug

    Lofexidine

    go.drugbank.com/drugs/DB04948
    ApprovedInvestigational

    Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. … [T210] Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and have fewer side effects than clonidine.

    Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline
  4. Drug

    LB-102

    go.drugbank.com/drugs/DB19214
    Investigational

    LB-102 is under investigation in clinical trial NCT06179108 (Randomized, Double-blinded, Placebo-controlled, Evaluating the Treatment With LB-102 in Patients With Acute Schizophrenia).

    Synonyms: Benzamide, n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-4-(methylamino)-, N'-methylamisulpride
  5. Drug

    LB-100

    go.drugbank.com/drugs/DB15412
    Investigational

    LB-100 is under investigation in clinical trial NCT03886662 (A Study of LB-100 in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS)).

    Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Lutetium Lu 177-DTPA-omburtamab

    go.drugbank.com/drugs/DB31015
    Investigational

    Lutetium Lu 177-DTPA-omburtamab is a radioimmunoconjugate made up of [omburtamab] conjugated with lutetium Lu 177 via the chelating agent of diethylenetriaminepentaacetic acid (DTPA).[L54566]

    Synonyms: Lutetium Lu 177-DTPA-omburtamab
  7. Drug

    DA-8031

    go.drugbank.com/drugs/DB19024
    Investigational

    DA-8031 is under investigation in clinical trial NCT01798667 (Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation).

    Categories: Heterocyclic Compounds, 2-RingSynonyms: 1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-1-(4-METHOXYPHENYL)-5-ISOBENZOFURANCARBONITRILE, 5-ISOBENZOFURANCARBONITRILE, 1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-1-(4-METHOXYPHENYL)-
  8. Drug

    Darapladib

    go.drugbank.com/drugs/DB06311
    Investigational

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    mRNA-1010

    go.drugbank.com/drugs/DB22484
    Approved

    confirmed in a postmarketing trial. … [L64058,L64060] It is administered as a single intramuscular dose.

  10. Drug

    LAX-101

    go.drugbank.com/drugs/DB05301
    Investigational

    LAX-101 treats hungtington’s disease, not just the symptoms but the disease itself. The active molecule in LAX-101 is Eicosapentaenoic Acid (EPA). All molecules of EPA are identical. … The molecules of EPA found in LAX-101 are identical to the molecules of EPA found in fish oil food supplements.