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Dronedarone
go.drugbank.com/drugs/DB04855ApprovedInvestigationalA safety concern for the risk of drug-induced hepatocellular injury has been issued following marketing of dronedarone.[L8800] … [A34604] This ultimately leads to reduced tissue accumulation of the drug and decreased risk for organ toxicities, such as thyroid and pulmonary toxicities.
Categories: Adrenergic alpha-1 Receptor Antagonists, P-glycoprotein inhibitorsSynonyms: N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamideEtripamil
go.drugbank.com/drugs/DB12605ApprovedInvestigational[A275243, A275248] The nasal formulation of etripamil was first approved by the FDA on December 12, 2025 for the conversion of acute symptomatic episodes of paroxysmal supraventricular tachycardia (PSVT
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigational[L32853] An extended-release granule formulation was subsequently granted approval in March 2021 for the treatment of pediatric patients with neurogenic detrusor overactivity. … [L32853] Mirabegron first received FDA approval in 2012, under the brand name Myrbetriq, for the treatment of adults with overactive bladder.
Categories: Drugs for Urinary Frequency and Incontinence, Adrenergic beta-3 Receptor AgonistsFluocortolone
go.drugbank.com/drugs/DB08971ApprovedWithdrawnFluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Categories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use, Corticosteroids for Systemic Use, PlainTAK-428
go.drugbank.com/drugs/DB05499ExperimentalTAK-428 is a drug for treating diabetic neuropathy. … It is based on the novel concept that peripheral nervous tissue that was damaged by diabetes can be repaired and regenerated by stimulating an increase in neurotrophic factors.
Zafirlukast
go.drugbank.com/drugs/DB00549ApprovedZafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. … Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily.
Categories: Drugs for Obstructive Airway Diseases, Cytochrome P-450 SubstratesPF-477736
go.drugbank.com/drugs/DB12611InvestigationalPF-00477736 has been used in trials studying the treatment of Neoplasms.
PF-04217903
go.drugbank.com/drugs/DB12848InvestigationalPF-04217903 has been used in trials studying the treatment of Neoplasms.
Arbekacin
go.drugbank.com/drugs/DB06696InvestigationalAn semisynthetic aminoglycoside antibiotic. Often used for treatment of multi-resistant bacterial infection such as methicillin-resistant _Staphylococcus aureus_ (MRSA).
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use