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Asciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigational[L38995,A241055] Asciminib received FDA approval on October 29, 2021 (Scemblix, Novartis AG).[L39000] … Existing inhibitors of ABL compete at the ATP binding sites of these proteins and can be classified into those that target the active conformation of the kinase domain ([dasatinib], [bosutinib]) and those
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsProducts: AZEVAY 20 MG FİLM KAPLI TABLET , 60 ADET, AZEVAY 40 MG FİLM KAPLI TABLET , 60 ADETGanciclovir
go.drugbank.com/drugs/DB01004ApprovedInvestigationalAn acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Synonyms: 2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone, 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanineCategories: MATE 1 Substrates, MATE 2 SubstratesRaltitrexed
go.drugbank.com/drugs/DB00293ApprovedInvestigationalRaltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsProducts: TOMUDEX 2 MG FLAKON, 1 ADET, TOMUDEX ® 2 MGVemurafenib
go.drugbank.com/drugs/DB08881ApprovedInvestigational[A31270] Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann La Roche. … After approval, Roche in collaboration with Genentech launched a broad development program. [L1012]
Categories: Antineoplastic and Immunomodulating Agents, Genito Urinary System and Sex HormonesProducts: ZELBORAF ® TABLETAS LACADAS DE 240 MG, ZELBORAF 240 MG FILM KAPLI TABLET ,56 FILM KAPLI TABLETRamosetron
go.drugbank.com/drugs/DB09290InvestigationalRamosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. … It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: IRRIBOW TABLET 5 MCG, NASEA(R) TABLET 0.1 MGTilmicosin
go.drugbank.com/drugs/DB11471InvestigationalVet approvedTilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with _Mannheimia haemolytica_.
Categories: P-glycoprotein substratesProducts: TILMICOSIN 100 mg/ml Oral Solution, Sahara Tilmicosin 10% w/w PowderRibociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalRibociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). … These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali.
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsProducts: KISQALI (200 MG), KISQALI 200 MG TABLETAS RECUBIERTASSaquinavir
go.drugbank.com/drugs/DB01232ApprovedInvestigationalSaquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. … In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a relatively benign adverse effect profile as compared
Categories: Metabolic Side Effects of Drugs and Substances, P-glycoprotein inducersProducts: SAQUINAVIR 500 MG TABLETAS., SAQUINAVIR 500 MG TABLETA RECUBIERTASulodexide
go.drugbank.com/drugs/DB06271ApprovedInvestigationalWithdrawnSulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).
Categories: Heparin and similars, Blood and Blood Forming OrgansProducts: ANJIOFLUX 600 LRU 2 ML ENJEKTABL COZELTI ICEREN 10 AMPUL, VESSEL DUE FEthionamide
go.drugbank.com/drugs/DB00609ApprovedInvestigationalWithdrawnA second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-ethyl-4-thiopyridylamide, 2-ethylthioisonicotinamide