Prednicarbate is a medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions. Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone.
- Mechanism
- Curator reviewed
In common with other topical corticosteroids, prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties. In general, the mechanism of the anti-inflammatory activity of topical steroids is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
- Primary indication
- For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.Curator reviewed · 1 structured indication
- Formula / weight
- C27H36O8 · 488.577 g/mol (avg)
- First approval
- Canada, 2020 · United States, 1991
- Code names
- LAS-189961 · S 77 0777
- Brand names
Resolves to
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Which drugs share a target with Prednicarbate, and which of those have an active Phase 3 trial?
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