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Ramipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. … ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).
Synonyms: (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acidMixtures: RAMIPLUS AL 5MG/25MG, RAMIPLUS AL 5MG/25MGOlmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigationalIn particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate fluid retention, vasoconstriction, and ultimately a further decline in left ventricular function. … ARBs such as olmesartan have been shown in a number of large-scale clinical outcomes trials to improve cardiovascular outcomes including reducing risk of myocardial infarction, stroke, the progression
Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid, 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acidMixtures: OLMEDOXTAN A®, OLMETAN® A 40/5 TABLETAS RECUBIERTASTeriflunomide
go.drugbank.com/drugs/DB08880ApprovedInvestigationalTeriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. … The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Synonyms: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidideCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersNADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
go.drugbank.com/bio_entities/BE0000093TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...
Synonyms: CI-13kD-A, Complex I-13kD-AProtein RecA
go.drugbank.com/bio_entities/BE0001269TargetMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA caus...
Synonyms: Recombinase ACardiolipin Biosynthesis CL(a-13:0/18:2(9Z,11Z)/a-13:0/a-21:0)
smpdb.ca/view/SMP0043344DiseaseLast, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor. … Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin.
Cardiolipin Biosynthesis CL(a-13:0/18:2(9Z,11Z)/a-13:0/a-25:0)
smpdb.ca/view/SMP0043345DiseaseLast, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor. … Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin.
Cardiolipin Biosynthesis CL(a-13:0/18:2(9Z,11Z)/a-15:0/a-17:0)
smpdb.ca/view/SMP0043361DiseaseLast, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor. … Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin.
Cardiolipin Biosynthesis CL(a-13:0/18:2(9Z,11Z)/a-15:0/a-25:0)
smpdb.ca/view/SMP0043363DiseaseLast, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor. … Newly synthesized cardiolipins undergo remodeling, a process carried out by the enzyme tafazzin.