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Displaying results 371 - 380 of 10000 in total
  1. Indication

    HRR gene-mutated (HRRm) metastatic castration-resistant prostate cancer (mCRPC)

    go.drugbank.com/conditions/DBCOND0159058
    Drugs: Talazoparib
    Synonyms: HRR gene-mutated (HRRm) metastatic castration-resistant prostate cancer (mCRPC)
  2. Drug

    Defibrotide

    go.drugbank.com/drugs/DB04932
    ApprovedInvestigational

    It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). … Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA.

  3. Drug

    Metformin

    go.drugbank.com/drugs/DB00331
    ApprovedInvestigational

    It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.

    Mixtures: AMARYL®M 1 MG/ 500 MG, AMARYL®M 4 MG/ 1000 MGCategories: MATE 1 Substrates, MATE 2 Substrates
  4. Drug

    EGEN-001

    go.drugbank.com/drugs/DB05953
    Investigational

    EGEN-001 is a novel non-viral vector consisting of a plasmid DNA encoding the human gene for interleukin 12 (IL-12) and a biocompatible, biodegradable delivery polymer with potential antineoplastic activity

    Synonyms: EGEN 001
  5. Drug

    Bromotheophylline

    go.drugbank.com/drugs/DB14018
    Approved

    From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. … Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline.

    Mixtures: Green Guard PMS Relief, Green Guard Cramp ReliefCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  6. Drug

    Odesivimab

    go.drugbank.com/drugs/DB15900
    ApprovedInvestigational

    [A221825, A221830] A recent large-scale study elucidated that both neutralizing and Fc-mediated functions of antibodies were important for therapeutic benefit in animal models of EBOV infection. … Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.

  7. Drug

    Tezacaftor

    go.drugbank.com/drugs/DB11712
    ApprovedInvestigational

    Alterations in the CFTR gene result in altered production, misfolding, or function of the protein and consequently abnormal fluid and ion transport across cell membranes. … [L4894] Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  8. Drug

    Amlodipine

    go.drugbank.com/drugs/DB00381
    ApprovedInvestigational

    Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. … Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than

    Synonyms: (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylateInternational brands: Amlodipine 5, Amlodipin-Mepha 5/10
  9. Drug

    Diethyltoluamide

    go.drugbank.com/drugs/DB11282
    Approved

    Diethyltoluamide (DEET) is the common active ingredient in many insect repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, DEET formulations are used to protect populations from mosquito-...

    Categories: Compounds used in a research, industrial, or household settingSynonyms: 3-methyl-N,N-diethylbenzamide, N,N-diethyl-m-toluamide
  10. Drug

    Lipoic acid

    go.drugbank.com/drugs/DB00166
    ApprovedInvestigationalNutraceutical

    A vitamin-like antioxidant.

    Mixtures: Live-wellâ„¢ MITOcareâ„¢ Liqfilâ„¢ Vegetable Capsule, Folic-KCategories: Vitamin B Complex, Compounds used in a research, industrial, or household setting