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Displaying results 3891 - 3900 of 5504 in total
  1. Target

    20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)

    go.drugbank.com/bio_entities/BE0009795
    EnzymeHumans and other mammals

    Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. Displays broad substrate specificity with distinct positional and stereochemistry, primarily generating 20alpha-hydroxysteroids, b...

    Synonyms: CHDR
  2. Drug

    Genistein

    go.drugbank.com/drugs/DB01645
    Investigational

    It has shown to be effective in the treatment of common liver fluke, pork trematode and poultry cestode. … It has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms.

  3. Drug

    Cinalukast

    go.drugbank.com/drugs/DB00587
    Experimental

    Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. … Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

    Synonyms: 3'-((E)-2-(4-cyclobutyl-2-thiazolyl)vinyl)-2,2-diethylsuccinanilic acid
  4. Drug

    Pimagedine

    go.drugbank.com/drugs/DB05383
    Investigational

    It is beneficial in treating patients with diabetic nephropathy. … It is an advanced glycation end product inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies.

  5. Drug

    Allovectin-7

    go.drugbank.com/drugs/DB17439
    Investigational

    It was discontinued after it failed to improve the objective response rate or overall survival versus first-line chemotherapy in malignant melanoma.[A255207]

  6. Drug

    Vapreotide

    go.drugbank.com/drugs/DB04894
    Investigational

    It was being studied for the treatment of cancer.

  7. Drug

    Teverelix

    go.drugbank.com/drugs/DB05624
    Investigational

    It has reached phase II clinical trials.

  8. Drug

    Alcuronium

    go.drugbank.com/drugs/DB13648
    Experimental

    It is used as an anesthesia adjuvant.

  9. Drug

    Mavorixafor

    go.drugbank.com/drugs/DB05501
    ApprovedInvestigational

    [L50642] It was first approved by the FDA on April 30, 2024, for the treatment of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a genetic immunodeficiency disorder characterized

  10. Drug

    Cytisine

    go.drugbank.com/drugs/DB09028
    Investigational

    Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. … Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost.