Cytisine is an alkaloid with partial agonist activity at the α4β2 nicotinic acetylcholine receptor used to aid smoking cessation. Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus.
- Mechanism
- Curator reviewed
Cytisine is a low efficacy partial agonist of ⍺4-β2 nicotinic acetylcholine receptors. These which are believed to be central to the effect of nicotine (NIC) on the reward pathway and facilitate addiction. Cytisine reduces the effects of NIC on dopamine release in the mesolimbic system when given alone, while simultaneously attenuating NIC withdrawal symptoms that accompany cessation attempts.
- Primary indication
- Indicated for use in smoking cessation.Curator reviewed · 1 structured indication
- Formula / weight
- C11H14N2O · 190.2417 g/mol (avg)
- Also known as
- Baptitoxine · Cytisinicline · Sophorine · Ulexin
Resolves to
ANJTVLIZGCUXLD-DTWKUNHWSA-NSMILESO=C1C=CC=C2[C@H]3CNC[C@H](C3)CN12What you can answer from here — as of July 18, 2025
Which drugs share a target with Cytisine, and which of those have an active Phase 3 trial?
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