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SNX-5422
go.drugbank.com/drugs/DB06070InvestigationalSNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. … As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingRenzapride
go.drugbank.com/drugs/DB04917InvestigationalRenzapride is currently in Phase III clinical development in the United States for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). … It has been suggested that renzapride is effective in the treatment of irritable bowel syndrome with alternating stool pattern. It is being developed by Alizyme of the UK.
Categories: Serotonin 5-HT4 Receptor AgonistsBeclamide
go.drugbank.com/drugs/DB09011ExperimentalBeclamide (N-benzyl-B-chloropropionamide) is a no longer used drug that possesses anticonvulsant and sedative activity.
NM-702
go.drugbank.com/drugs/DB05505InvestigationalIntermittent claudication is a major symptom of arteriosclerosis obliterans. … M-702 is an orally active inhibitor of phosphodiesterase and thromboxane synthetase.
Categories: Heterocyclic Compounds, 1-RingAzvudine
go.drugbank.com/drugs/DB16407InvestigationalAzvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)).
Categories: Heterocyclic Compounds, 1-RingNNZ-2591
go.drugbank.com/drugs/DB15601InvestigationalNNZ-2591 (cyclo-L-glycyl-L-2-allylproline)[A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been … [L11106] It is currently under development by Neuren Pharmaceuticals for the symptomatic treatment of Angelman, Phelan-McDermid, and Pitt Hopkins Syndromes.
Categories: Heterocyclic Compounds, 1-RingSynonyms: Cyclo(-L-glycyl-L-2-allylproline), Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-8a-(2-propenyl)-, (8aR)-Ciluprevir
go.drugbank.com/drugs/DB05868InvestigationalThe compound, named BILN 2061, is an orally active inhibitor of the HCV NS3 protease and the first member of this new drug class to be tested in humans.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingCT-011
go.drugbank.com/drugs/DB05916InvestigationalIt is directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities. … CT-011 is a humanized monoclonal antibody directed against a B7 family-associated protein, in patients with advanced haematological malignancies.
Voacamine
go.drugbank.com/drugs/DB04877ExperimentalVoacamine is an alkaloid isolated from the bark of the _Pescheria fuchsiae folia_ tree. It is an antimalarial drug approved for use in several African countries. … Voacamine is also under investigation for use in modulating multidrug-resistance in tumor cells.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 2-RingErythrityl tetranitrate
go.drugbank.com/drugs/DB01613ApprovedWithdrawnA vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)