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Piroctone
go.drugbank.com/drugs/DB15946InvestigationalRecently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.[L34189] … Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
HNM01
go.drugbank.com/drugs/DB06531ExperimentalIt entered Phase 1 clinical trials for the treatment of HIV infections but was discontinued during this phase … The drug hNM01, a humanized monoclonal antibody developed by SRD Pharmaceuticals, Inc., targets the V(3) region of the HIV-1 envelope protein gp120, functioning as an HIV replication inhibitor.
Betaprodine
go.drugbank.com/drugs/DB01473ExperimentalIllicitIt has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)
Flupirtine
go.drugbank.com/drugs/DB06623InvestigationalFlupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe.
Alprenolol
go.drugbank.com/drugs/DB00866ApprovedWithdrawnOne of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.
PW2101
go.drugbank.com/drugs/DB06483ExperimentalThe development of PW2101 has since been discontinued. … The drug was developed by Penwest Pharmaceuticals and in 2005 the FDA issues a Non-Approval letter due to the degree of kinetic variability of PW2101 observed among individuals.
Dengue virus serotype 4
go.drugbank.com/drugs/DB22667Approved[L53368] Qdenga was approved for use in the European Union in December 2022.[L53373]
Dexfenfluramine
go.drugbank.com/drugs/DB01191ApprovedIllicitWithdrawnHowever, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Tasosartan
go.drugbank.com/drugs/DB01349ExperimentalIts long duration of action has been attributed to its active metabolite enoltasosartan. It is used to treat patients with essential hypertension.
Bezafibrate
go.drugbank.com/drugs/DB01393ApprovedInvestigationalAntilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
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