One of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. Alprenolol is no longer marketed by AstraZeneca, but may still be available in generic varieties.
- Mechanism
- Curator reviewed
Alprenolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. Also, with a more minor effect, by binding beta-2 receptors in the juxtaglomerular apparatus, alprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
- Primary indication
- For the treatment of hypertension, angina, and arrhythmiaCurator reviewed
- Formula / weight
- C15H23NO2 · 249.3486 g/mol (avg)
- Also known as
- Aprenololo
- Code names
- H 561/28 · H 56/28
Resolves to
PAZJSJFMUHDSTF-UHFFFAOYSA-NSMILESCC(C)NCC(O)COC1=CC=CC=C1CC=CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Alprenolol, and which of those have an active Phase 3 trial?
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