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Displaying results 3951 - 3960 of 10000 in total
  1. Drug

    Nangibotide

    go.drugbank.com/drugs/DB16247
    Investigational

    Nangibotide is under investigation in clinical trial NCT04055909 (Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock).

    Categories: Heterocyclic Compounds, 3-Ring
  2. Drug

    SSR-126517E

    go.drugbank.com/drugs/DB05362
    Experimental

    SSR-126517E is a second generation synthetic pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of 80 hours.

  3. Drug

    Cerulenin

    go.drugbank.com/drugs/DB01034
    Experimental

    In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity.

    Synonyms: (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide, (2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide
  4. Drug

    Palivizumab

    go.drugbank.com/drugs/DB00110
    ApprovedInvestigational

    The human lightchain sequence was derived from the constant domain of Ck and the variable framework regions of the VL gene K104 withJk-4. … Synagis is a composite of human (95%) and murine (5%) antibody sequences.

    Categories: Respiratory Syncytial Virus Anti-F Protein Monoclonal AntibodyProducts: SYNAGIS 100 MG/1 ML IM ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON,1 ADET, SYNAGIS® 50 MG
  5. Drug

    Copper histidinate

    go.drugbank.com/drugs/DB32041
    Approved

    Menkes disease is a rare, X-linked recessive disorder caused by pathogenic variants in the ATP7A gene, which encodes a copper transport protein essential for absorbing dietary copper and transporting it … [A275383] Copper histidinate is a subcutaneously-administered copper-histidine complex that allows for copper supplementation in patients with defective ATP7A transporters.

  6. Drug

    Obinutuzumab

    go.drugbank.com/drugs/DB08935
    ApprovedInvestigational

    [A274631] Structurally, obinutuzumab is glycoengineered, meaning the fucose content of its Fc region has been reduced. … Obinutuzumab is a humanized anti-CD20 monoclonal antibody designed to treat B-cell malignancies.

    Products: GAZYVA 1000 MG IV İNFÜZYONLUK KONSANTRE ÇÖZELTİ, 1 ADET, GAZYVA ® CONCENTRADO PARA SOLUCIÓN PARA INFUSIÓN 1000 MG / VIAL 40 ML
  7. Drug

    Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine

    go.drugbank.com/drugs/DB10061
    ApprovedInvestigational

    [A253277] Several serogroups of _N. meningitidis_ - A, B, C, Y, and W-135 - known to cause meningococcal infections have been identified. … [A253277] Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine contains serogroup A, C, Y, and W-135 oligosaccharides conjugated individually to _Corynebacterium

    Synonyms: Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine
  8. Drug

    Bacillus calmette-guerin substrain russian BCG-I live antigen

    go.drugbank.com/drugs/DB16648
    ApprovedInvestigational

    Live BCG vaccines administered intravesically have been a gold standard therapy in the adjuvant treatment of non-muscle-invasive bladder cancers for decades,[A232264] used after tumor resection, and are … [L32729,A232264] The live Russian BCG-I substrain of BCG was granted a notice of compliance with conditions by Health Canada in February 2021.

    Synonyms: Bacillus Calmette-Guérin (BCG) - strain russian BCG-I, Bacillus calmette-guerin substrain russian BCG-I live antigen
  9. Drug

    Deflazacort

    go.drugbank.com/drugs/DB11921
    Approved

    [L6694] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which is important for muscle function. … Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD).

    Synonyms: 5'H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE, 21-(ACETYLOXY)-11-HYDROXY-2'-METHYL-, (11.BETA.,16.BETA.)-, 11.BETA.,21-DIHYDROXY-2'-METHYL-5'.BETA.H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE 21-ACETATECategories: Corticosteroid Hormone Receptor Agonists, Cytochrome P-450 Substrates
  10. Drug

    Pizotifen

    go.drugbank.com/drugs/DB06153
    Approved

    [A32532] It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. … Sandomigran is available in a number of countries but is not approved by the FDA nor EMA.

    Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT1 Receptor Antagonists