Cerulenin is an antifungal agent whose activity interferes with or otherwise acts to prevent the formation of fatty acids and sterols. In fatty acid synthesis, reported to bind in equimolar... In sterol synthesis, inhibits HMG-CoA synthetase activity.
- Mechanism
- Curator reviewed
Irreversibly binds to fatty acid synthase, specifically b-ketoacyl-acyl carrier protein synthase (FabH, FabB and FabF condensation enzymes). A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.
- Primary indication
- For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animalsCurator reviewed
- Formula / weight
- C12H17NO3 · 223.272 g/mol (avg)
- Code names
- NSC-116069
Resolves to
GVEZIHKRYBHEFX-NQQPLRFYSA-NSMILES[H][C@]1(O[C@]1([H])C(=O)CC\C=C\C\C=C\C)C(N)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Cerulenin, and which of those have an active Phase 3 trial?
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