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Tradipitant
go.drugbank.com/drugs/DB12580ApprovedInvestigational[A275353] Approved by the FDA on December 30, 2025, tradipitant is indicated for the prevention of vomiting induced by motion. … [L54903] NK-1 receptors are expressed in the brainstem and nucleus tractus solitarius, which receives emetogenic signals from various stimuli including dizziness and vertigo.
Categories: Substance P/Neurokinin-1 Receptor Antagonist, P-glycoprotein substratesSynonyms: (2-(1-(3,5-BIS(TRIFLUOROMETHYL)BENZYL)-5-PYRIDIN-4-YL-1H-1,2,3-TRIAZOL-4-YL)PYRIDIN-3-YL)(2-CHLOROPHENYL)METHANONE, METHANONE, (2-(1-((3,5-BIS(TRIFLUOROMETHYL)PHENYL)METHYL)-5-(4-PYRIDINYL)-1H-1,2,3-TRIAZOL-4-YL)-3-PYRIDINYL)(2-CHLOROPHENYL)-Nitroprusside
go.drugbank.com/drugs/DB00325ApprovedInvestigationalNitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. … Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles).
Categories: Compounds used in a research, industrial, or household settingProducts: NITROPRUSIATO DE SODIO 50 MG/2 ML INYECTABLE, NITROPRUSIATO DE SODIO SOLUCION INYECTABLE POR 2 MLN-Alkyl dimethyl benzyl ammonium chloride (C12-C18)
go.drugbank.com/drugs/DB16590InvestigationalMixtures: SINBIO Sanitizer S-300Fesoterodine
go.drugbank.com/drugs/DB06702ApprovedFesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: TOVIAZ 4 MG, TOVIAZ 4 mg prolonged-release tabletsChlormadinone
go.drugbank.com/drugs/DB13528InvestigationalMixtures: ADELLA MINI TABLETA CON RECUBRIMIENTO DE GELATINA, ADELLA MINI TABLETA CON RECUBRIMIENTO DE GELATINACategories: Sex Hormones and Modulators of the Genital System, P-glycoprotein inhibitorsBinimetinib
go.drugbank.com/drugs/DB11967ApprovedInvestigationalwith unresectable or metastatic melanoma with the BRAF V600E or V600K mutations, as detected by an FDA-approved test. … [A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array BioPharma Inc.) in combination for patients
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: MEKTOVI® 15 MG TABLETAS RECUBIERTASFenbufen
go.drugbank.com/drugs/DB08981ApprovedIt can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. … Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.
Categories: Non COX-2 selective NSAIDSSynonyms: 4-(4-Biphenylyl)-4-oxobutyric acid, 3-(4-Phenylbenzoyl)propionic acidPegunigalsidase alfa
go.drugbank.com/drugs/DB14992ApprovedInvestigational[A259347,A259352] In May 2023, the EMA granted marketing authorization to pegunigalsidase alfa in the European Union (EU) for the treatment of adult patients with Fabry disease. … to a different glycosylation pattern.
Talazoparib
go.drugbank.com/drugs/DB11760ApprovedInvestigational[L47301] Talazoparib is currently used in the treatment of BRCA-mutated breast cancer and HRR-mutated prostate cancer.[L47236, L47301, L47306] … [L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and by the EMA in June 2019.[L47296] It was approved by Health Canada in September 2020.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesAT-GTX-502
go.drugbank.com/drugs/DB17001ExperimentalAT-GTX-502 is an experimental, one-time gene therapy that uses AAV9 to deliver a functional copy of CLN3.
Categories: Non-Replicating Recombinant, Self-Complementary Adeno-Associated Virus Serotype 9 Containing the Human CLN3 Gene