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Canrenoic acid
go.drugbank.com/drugs/DB09015ApprovedInvestigationalWithdrawnCanrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist. Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
Categories: Mineralocorticoid Receptor AntagonistsPerospirone
go.drugbank.com/drugs/DB08922InvestigationalIt is also shown to be less associated with extrapyramidal symptoms as a side effect compared to [DB00502]. … It is commonly present as the hydrated hydrochloride salt form.
Categories: Dopamine D2 Receptor AntagonistsTrichloroethylene
go.drugbank.com/drugs/DB13323ApprovedTrichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. … Environmental exposure, particularly groundwater and drinking water contamination from industrial discharge, is a major concern for human health and has been the subject of numerous incidents and lawsuits
Synonyms: TCESteroidogenic factor 1
go.drugbank.com/bio_entities/BE0003359TargetHumansTranscriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B a...
Synonyms: Steroid hormone receptor Ad4BP, Nuclear receptor subfamily 5 group A member 15-methoxy-N,N-dimethyltryptamine
go.drugbank.com/drugs/DB14010IllicitInvestigationalThis drug, as well as [dimethyltryptamine] and [bufotenin], have been registered to be used in South America in religious and spiritual rituals. … It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin Receptor AgonistsAfatinib
go.drugbank.com/drugs/DB08916ApprovedInvestigationalGilotrif (afatinib) is the first FDA-approved oncology product from Boehringer Ingelheim [L2939]. … Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label].
Categories: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitorsTafamidis
go.drugbank.com/drugs/DB11644ApprovedInvestigational[A189717] Tafamidis is structurally similar to diflusinal.[A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]
Janus (JAK) kinases
go.drugbank.com/bio_entities/BE0027976TargetHumansThe heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 … Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR
Polypeptides: Non-receptor tyrosine-protein kinase TYK2Function: acetylcholine receptor bindingPoa pratensis pollen
go.drugbank.com/drugs/DB10366ApprovedPoa pratensis pollen is the pollen of the Poa pratensis plant. Poa pratensis pollen is mainly used in allergenic testing.
Mixtures: K-O-T Standardized Grass Pollen Mix, K-O-T Standardized Grass Pollen MixRentiapril
go.drugbank.com/drugs/DB20567ExperimentalThe usage of the INN stem '-pril' in the name indicates that Rentiapril is a angiotensin-converting enzyme inhibitor. Rentiapril has a monoisotopic molecular weight of 313.04 Da.
Categories: Agents Acting on the Renin-Angiotensin System