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Pipamperone
go.drugbank.com/drugs/DB09286InvestigationalPipamperone is a typical antipsychotic of the _butyrophenone_ family used in the treatment of schizophrenia. … Interestingly, when [risperidone] was created, Janssen suggested it was a more potent version of pipamperone.
Categories: Dopamine D2 Receptor AntagonistsFinasteride
go.drugbank.com/drugs/DB01216ApprovedInvestigational[L6244,L10565] In 1998, it was approved by the FDA to treat male pattern hair loss. … It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects.
Products: Sandoz Finasteride A, FINASTERID 1A PHARMA 5MGValganciclovir
go.drugbank.com/drugs/DB01610ApprovedInvestigationalAs the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Categories: Cytomegalovirus Nucleoside Analog DNA Polymerase InhibitorOliceridine
go.drugbank.com/drugs/DB14881ApprovedInvestigational[A218026, A218031] By acting as a biased agonist, oliceridine provides comparable analgesia compared with traditional opioids such as [morphine] at a comparable or decreased risk of opioid-related adverse … [A218041] Oliceridine gained FDA approval on August 7, 2020, and is currently marketed by Trevena Inc as OLINVYK™.[L15516]
Tetradecyl hydrogen sulfate (ester)
go.drugbank.com/drugs/DB11328ApprovedAlso noted was an unspecified number of episodes of epidermal necrosis without significant long-term effects and a 30% incidence of post-sclerosis pigmentation that resolved within a few months [L2035] … Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report of injecting a 1% solution into spider angiomas in 144 patients was made.
Rice bran oil
go.drugbank.com/drugs/DB11293ApprovedInvestigationalRice bran oil is classified as an indirect additive used in food contact substances by the FDA.
Categories: Complex MixturesHydrogenated soybean oil
go.drugbank.com/drugs/DB11302ApprovedAccording to the FDA, hydrogenated soybean oil is generally recognized as safe (GRAS) food substance. … Extracted from the seeds of the soybean (Glycine soja), hydrogenated soybean oil is a major food fat used in the production of margarine, shortening, and salad and cooking oils.
Lucinactant
go.drugbank.com/drugs/DB04897ApprovedFDA approved on March 6, 2012. … Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use.
Obecabtagene autoleucel
go.drugbank.com/drugs/DB17362ApprovedInvestigationalObecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [A265050] On November 8, 2024, obecabtagene autoleucel was approved by the FDA for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
Synonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODINGReserpine
go.drugbank.com/drugs/DB00206ApprovedWithdrawnThe FDA withdrew its approval for the use of all oral dosage form drug products containing more than 1 mg of reserpine.[L43942] … It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.