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Displaying results 4351 - 4360 of 10000 in total
  1. Drug

    Trastuzumab

    go.drugbank.com/drugs/DB00072
    ApprovedInvestigational

    Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody [A40276] that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular … [L14015] It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast cancer, where there is a proven amplification of the HER-2 oncogene or over-expression of the HER

    Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  2. Drug

    Casdozokitug

    go.drugbank.com/drugs/DB17513
    Investigational

    Synonyms: ), CDR-IMGT [8.8.19] (26-33.51-58.97-115)) (1-126), immunoglobulin G1-kappa, anti-[IL27 (interleukin 27,IL27p28, IL27A)], Homo sapiens monoclonal antibody,gamma1 heavy chain Homo sapiens (1-456) [VH (Homo sapiens IGHV3-21*01 (95.9%) -(IGHD) -IGHJ5*02 (100%
  3. Drug

    RP-72

    go.drugbank.com/drugs/DB17156
    Investigational

    Synonyms: CXC chemokine receptor types 1 and 2 inhibitor RP72, 72 amino acid proprietary recombinant protein antagonist for the CXCR1 and CXCR2 receptors of interleukin-8
  4. Drug

    Loperamide

    go.drugbank.com/drugs/DB00836
    ApprovedInvestigational

    [A251610] It is a highly lipophilic synthetic phenylpiperidine opioid that works by binding to mu-opioid receptors on intestinal muscles to decrease intestinal motility and electrolyte loss. … [A251610] Loperamide has a chemical structure that is similar to diphenoxylate and haloperidol;[A6249] however, loperamide works on mu (μ)-opioid receptors to mediate its pharmacological actions.

    Mixtures: Dg Health Anti Diarrheal Anti Gas, Meds on the GoCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates
  5. Drug

    Antihemophilic factor human

    go.drugbank.com/drugs/DB13192
    ApprovedInvestigational

    Endogenous Factor VIII is essential to the clotting process in the body due to its involvement in the clotting cascade where it is responsible for acting as a co-factor to Factor IX. … with conventional factor VIII due to conjugation to the dimeric Fc domain of human immunoglobulin G1, a long-lived plasma protein [A31551].

    Mixtures: BERIPLAST-P COMBI SET 1 ML TROMBİN ÇÖZELTİSİ VE 1 ML FİBRİNOJEN ÇÖZELTİSİ İÇEREN FİBRİN YAPIŞTIRICI, BERIPLAST-P COMBI SET 3 ML TROMBİN ÇÖZELTİSİ VE 1 ML FİBRİNOJEN ÇÖZELTİSİ İÇEREN FİBRİN YAPIŞTIRICICategories: Hemophilia A
  6. Drug

    Ivabradine

    go.drugbank.com/drugs/DB09083
    ApprovedInvestigational

    Therefore, as ivabradine is designed as a "pure" heart rate-lowering drug by selectively acting on the If channels, it may offer a more favorable side effect profile due to its lower likelihood of causing … Ivabradine acts by selectively inhibiting the "funny" channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the

    Mixtures: Implicor 50 mg/5 mg Filmtabletten, IMPLICOR FILM-COATED TABLET 50 mg/5 mgCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  7. Drug

    Hydrotalcite

    go.drugbank.com/drugs/DB13322
    ApprovedInvestigationalWithdrawn

    Products: HIDROTIZ® TABLETA MASTICABLE 500 MG, TALCID® COMPRIMIDOS MASTICABLES 500 MG
  8. Drug

    Forodesine

    go.drugbank.com/drugs/DB06185
    Investigational

    Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic … leukemia and cutaneous T-cell lymphoma.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: 1,4-Dideoxy-4-aza-1-(S)-(9-deazahypoxanthin-9-yl)-D-ribitol, (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol
  9. Drug

    Tasadenoturev

    go.drugbank.com/drugs/DB17178
    Investigational

    Synonyms: Tumor-selective delta-24 ,rgd modified adenovirus serotype 5, adenovirus delta 24-RGD, an oncolytic adenovirus genetically modified for treatment of glioma
  10. Drug

    (E)-(4S,6S)-6-((S)-2-{(S)-2-[(FURAN-2-CARBONYL)-AMINO]-3-METHYL-BUTYRYLAMINO}-3-METHYL-BUTYRYLAMINO)-8-METHYL-5-OXO-4-((R)-2-OXO-PYRROLIDIN-3-YLMETHYL)-NON-2-ENOIC ACID ETHYL ESTER

    go.drugbank.com/drugs/DB04613
    Experimental

    Synonyms: (E)-(4S,6S)-6-((S)-2-{(S)-2-[(FURAN-2-CARBONYL)-AMINO]-3-METHYL-BUTYRYLAMINO}-3-METHYL-BUTYRYLAMINO)-8-METHYL-5-OXO-4-((R)-2-OXO-PYRROLIDIN-3-YLMETHYL)-NON-2-ENOIC ACID ETHYL ESTER