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Displaying results 431 - 440 of 10000 in total
  1. Drug

    Brensocatib

    go.drugbank.com/drugs/DB15638
    Approved

    [A274348] Brensocatib is a first-in-class dipeptidyl peptidase 1 (DPP1) inhibitor that inhibits neutrophil serine proteases, addressing a key driver of this inflammation. … [A274348,A274343] It reduces exacerbations and slows lung function decline, offering a targeted approach to managing NCFB.

    Synonyms: (S)-N-((S)-1-Cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo-(d)oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamideCategories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-Ring
  2. Drug

    Etoricoxib

    go.drugbank.com/drugs/DB01628
    ApprovedInvestigationalWithdrawn

    Etoricoxib is a new COX-2 selective inhibitor. … It is approved in more than 60 countries worldwide but not in the US.

    Mixtures: DOSCOXEL-DUOCategories: Heterocyclic Compounds, 1-Ring, COX-2 Inhibitors
  3. Drug

    Propofol

    go.drugbank.com/drugs/DB00818
    ApprovedInvestigationalVet approved

    IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. … Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia.

    Synonyms: 2,6-bis(1-methylethyl)phenolInternational brands: Oleo-Lax
  4. Drug

    Sofosbuvir

    go.drugbank.com/drugs/DB08934
    ApprovedInvestigational

    Approved in October 2014 by the FDA, Harvoni is indicated for the treatment of HCV genotypes 1, 4, 5, and 6 with or without [DB00811] depending on the level of liver damage or cirrhosis [FDA Label]. … Notably, sofosbuvir has come under intense scrutiny since its release to market in 2013. With the price per pill set at $1000, a 12-week treatment can cost upwards of $84,000 per patient [A19636].

    Mixtures: HARVONI®, EPCLUSA®Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates
  5. Drug

    1-Hydroxy-1-Thio-Glycerol

    go.drugbank.com/drugs/DB01684
    Experimental

    Synonyms: 1-Hydroxy-1-Thio-Glycerol
  6. Drug

    Lomifylline

    go.drugbank.com/drugs/DB18002
    Approved

    Synonyms: 7-(5-oxohexyl)theophyllineCategories: Heterocyclic Compounds, 2-Ring
  7. Drug

    1-Amino-1-Carbonyl Pentane

    go.drugbank.com/drugs/DB03241
    Experimental

    Synonyms: 1-Amino-1-Carbonyl Pentane
  8. Drug

    MC-1

    go.drugbank.com/drugs/DB05315
    Experimental

    Medicure's MC-1 drug is a cardio-protectant, designed to reduce the damage to the heart when arteries are blocked and when they are subsequently reopened after bypass surgery.

    Synonyms: MC-1
  9. Drug

    1-benzylimidazole

    go.drugbank.com/drugs/DB04581
    Experimental

    1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-benzyl-1H-imidazole, 1-benzylimidazole
  10. Drug

    IDD-1

    go.drugbank.com/drugs/DB05439
    Experimental

    Eladem (IDD-1) is a therapeutic vaccine consisting of dendritophages that are loaded in vitro with tumor antigens and then reinjected into the subject. … As with other monoclonal antibodies, this process stimulates an immune response to a particular disease-related antigen.

    Synonyms: IDD-1International brands: Eladem-2