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Lomifylline

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Lomifylline
DrugBank Accession Number
DB18002
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
3D
Similar Structures
Weight
Average: 278.312
Monoisotopic: 278.137890456
Chemical Formula
C13H18N4O3
Synonyms
  • 7-(5-oxohexyl)theophylline
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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1,2-BenzodiazepineThe therapeutic efficacy of 1,2-Benzodiazepine can be decreased when used in combination with Lomifylline.
AcebutololThe risk or severity of adverse effects can be increased when Acebutolol is combined with Lomifylline.
AcetazolamideAcetazolamide may increase the excretion rate of Lomifylline which could result in a lower serum level and potentially a reduction in efficacy.
AdalimumabThe serum concentration of Lomifylline can be decreased when it is combined with Adalimumab.
AdenosineThe therapeutic efficacy of Adenosine can be decreased when used in combination with Lomifylline.
Food Interactions
Not Available

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Categories

ATC Codes
R03DA20 — Combinations of xanthines
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
NA91GV8GDJ
CAS number
10226-54-7
InChI Key
XBEDAMVJWVPVDS-UHFFFAOYSA-N
InChI
InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-8-14-11-10(17)12(19)16(3)13(20)15(11)2/h8H,4-7H2,1-3H3
IUPAC Name
1,3-dimethyl-7-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
SMILES
CN1C2=C(N(CCCCC(C)=O)C=N2)C(=O)N(C)C1=O

References

General References
Not Available
ChemSpider
59040
RxNav
164423
ChEBI
94702
ChEMBL
CHEMBL311948
ZINC
ZINC000002020029

Clinical Trials

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Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.23Chemaxon
pKa (Strongest Acidic)19.64Chemaxon
pKa (Strongest Basic)-1.2Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area75.51 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity73.52 m3·mol-1Chemaxon
Polarizability29.16 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at August 31, 2023 17:15 / Updated at September 02, 2023 00:24