This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Lomifylline
- DrugBank Accession Number
- DB18002
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Lomifylline (DB18002)
- Weight
- Average: 278.312
Monoisotopic: 278.137890456 - Chemical Formula
- C13H18N4O3
- Synonyms
- 7-(5-oxohexyl)theophylline
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The therapeutic efficacy of 1,2-Benzodiazepine can be decreased when used in combination with Lomifylline. Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Lomifylline. Acetazolamide Acetazolamide may increase the excretion rate of Lomifylline which could result in a lower serum level and potentially a reduction in efficacy. Adalimumab The serum concentration of Lomifylline can be decreased when it is combined with Adalimumab. Adenosine The therapeutic efficacy of Adenosine can be decreased when used in combination with Lomifylline. - Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- R03DA20 — Combinations of xanthines
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- NA91GV8GDJ
- CAS number
- 10226-54-7
- InChI Key
- XBEDAMVJWVPVDS-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-8-14-11-10(17)12(19)16(3)13(20)15(11)2/h8H,4-7H2,1-3H3
- IUPAC Name
- 1,3-dimethyl-7-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
- SMILES
- CN1C2=C(N(CCCCC(C)=O)C=N2)C(=O)N(C)C1=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 59040
- 164423
- ChEBI
- 94702
- ChEMBL
- CHEMBL311948
- ZINC
- ZINC000002020029
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.23 Chemaxon pKa (Strongest Acidic) 19.64 Chemaxon pKa (Strongest Basic) -1.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 75.51 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 73.52 m3·mol-1 Chemaxon Polarizability 29.16 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at August 31, 2023 17:15 / Updated at September 02, 2023 00:24