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Displaying results 4431 - 4440 of 8196 in total
  1. Drug

    Gefitinib

    go.drugbank.com/drugs/DB00317
    ApprovedInvestigational

    Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is ma...

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  2. Drug

    Defactinib

    go.drugbank.com/drugs/DB12282
    ApprovedInvestigational

    Defactinib is a small molecule kinase inhibitor targeted against focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (Pyk2), the two members of the FAK family of nonreceptor tyrosine kinases. FAK is important for the integrin-...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers
  3. Drug

    Zongertinib

    go.drugbank.com/drugs/DB18762
    ApprovedInvestigational

    Zongertinib is a selective, irreversible tyrosine kinase inhibitor that targets human epidermal growth factor receptor 2 (HER2). It covalently binds to the HER2 receptor, including exon 20 insertions, and inhibits downstream signaling pa...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  4. Drug

    Orforglipron

    go.drugbank.com/drugs/DB18964
    ApprovedInvestigational

    Orforglipron is a first-in-class oral, non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist. Developed to circumvent the adherence barriers and strict administration requirements of peptide-based GLP-1 therapies, its small-molecu...

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  5. Drug

    TU-100

    go.drugbank.com/drugs/DB12467
    Investigational

    TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others.

  6. Drug

    Tesevatinib

    go.drugbank.com/drugs/DB11973
    Investigational

    In addition, tesevatinib inhibits EphB4, an RTK that is highly expressed in many human tumors and plays a role in promoting angiogenesis.

  7. Drug

    Mebenil

    go.drugbank.com/drugs/DB14728
    Experimental

    An obsolete fungicide used to control various pathogens on cereals and seed potatoes.

  8. Drug

    VO659

    go.drugbank.com/drugs/DB18160
    Investigational

    VO659 is an antisense oligonucleotide being investigated for the treatment of Huntington's disease.

    Synonyms: an antisense oligonucleotide that has been developed to target expanded CAG repeats in messenger ribonucleic acid (mRNA)
  9. Drug

    VG161

    go.drugbank.com/drugs/DB18469
    Investigational

    VG161 is an oncolytic virus therapy under investigation for the treatment of cholangiocarcinoma.

  10. Drug

    BG1805

    go.drugbank.com/drugs/DB18667
    Investigational

    BG1805 is an investigational anti-CLL1 chimeric antigen receptor (CAR) T-cell therapy.