Orforglipron
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Orforglipron
- DrugBank Accession Number
- DB18964
- Background
Orforglipron is under investigation in clinical trial NCT06010004 (A Long-term Safety Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 882.974
Monoisotopic: 882.377721012 - Chemical Formula
- C48H48F2N10O5
- Synonyms
- 1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dim
- 3-[(1S,2S)-1-({2-(4-fluoro-3,5-dimethylphenyl)-3-({3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}carbonyl)-5-[(4S)-2,2-dimethyloxan-4-yl]-1H-indol-1-yl}-2-methylcyc
- Orforglipron
- External IDs
- LY-3502970
- LY3502970
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7ZW40D021M
- CAS number
- 2212020-52-3
- InChI Key
- USUWIEBBBWHKNI-KHIFEHGGSA-N
- InChI
- InChI=1S/C48H48F2N10O5/c1-25-18-32(19-26(2)40(25)49)60-42(58-16-15-57(46(58)63)37-11-10-36-33(41(37)50)24-51-55(36)7)39-28(4)56(14-12-34(39)53-60)43(61)38-21-31-20-29(30-13-17-64-47(5,6)23-30)8-9-35(31)59(38)48(22-27(48)3)44-52-45(62)65-54-44/h8-11,15-16,18-21,24,27-28,30H,12-14,17,22-23H2,1-7H3,(H,52,54,62)/t27-,28-,30+,48-/m1/s1
- IUPAC Name
- SMILES
- [H][C@@]1(CCOC(C)(C)C1)C1=CC=C2N(C(=CC2=C1)C(=O)N1CCC2=NN(C(N3C=CN(C3=O)C3=CC=C4N(C)N=CC4=C3F)=C2[C@@H]1C)C1=CC(C)=C(F)C(C)=C1)[C@]1(C[C@@H]1C)C1=NOC(=O)N1
References
- General References
- Not Available
- External Links
- ChemSpider
- 71117507
- BindingDB
- 50514045
- ChEMBL
- CHEMBL4446782
- PDBe Ligand
- V6G
- Wikipedia
- Orforglipron
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Active Not Recruiting Treatment Obesity 1 somestatus stop reason just information to hide 3 Active Not Recruiting Treatment Obesity / Overweight / Overweight or Obesity 1 somestatus stop reason just information to hide 3 Active Not Recruiting Treatment Obesity / Overweight / Type 2 Diabetes Mellitus 1 somestatus stop reason just information to hide 3 Active Not Recruiting Treatment Type 2 Diabetes Mellitus 2 somestatus stop reason just information to hide 3 Recruiting Treatment Cardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Obesity / Overweight / Overweight or Obesity / Type 2 Diabetes Mellitus 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at June 27, 2024 16:55 / Updated at June 28, 2024 04:46