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Displaying results 441 - 450 of 10000 in total
  1. Drug

    Entrectinib

    go.drugbank.com/drugs/DB11986
    ApprovedInvestigational

    [L8207] Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval based on early trial data. … This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.[A183929]

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide
  2. Drug

    Sulfaethoxypyridazine

    go.drugbank.com/drugs/DB11462
    ExperimentalVet approved

    Synonyms: 4-amino-N-(6-ethoxy-3-pyridazinyl)benzenesulfonamide, N1-(6-ethoxy-3-pyridazinyl)sulfanilamide
  3. Drug

    Flurbiprofen

    go.drugbank.com/drugs/DB00712
    ApprovedInvestigational

    Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.

    Mixtures: FULDUO 100 MG/8 MG FİLM KAPLI TABLET, 14 ADET, MULTIFLEX 200/8 MG SR KAPSUL, 14 ADETCategories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDS
  4. Drug

    Midostaurin

    go.drugbank.com/drugs/DB06595
    ApprovedInvestigational

    Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. … It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108].

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 InducersSynonyms: 4'-N-benzoylstaurosporine
  5. Drug

    Titanium dioxide

    go.drugbank.com/drugs/DB09536
    Approved

    It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.

    Mixtures: Babo Botanicals Daily Sheer Mineral Sunscreen SPF 40, Babo Botanicals Daily Sheer Mineral Sunscreen SPF 40Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    POT-4

    go.drugbank.com/drugs/DB06056
    Investigational

    POT-4 is a peptide that specifically inhibits complement activation and is initially being developed for the treatment of age-related macular degeneration (AMD). … The investigational drug was under investigation in clinical trial NCT00473928 (Safety of Intravitreal POT-4 Therapy for Patients With Neovascular Age-Related Macular Degeneration (AMD) (ASaP)).

  7. Drug

    IDM-4

    go.drugbank.com/drugs/DB05438
    Experimental

    IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of Leukemia. … It is a monoclonal antibody-specific antigen that can selectively target cancer-affected cells by coupling with tumor cell-killing MAK cells, which are derived from the patient's own monocytes.

    Synonyms: IDM-4
  8. Drug

    4-dimethylaminophenol

    go.drugbank.com/drugs/DB13549
    Experimental

    Salts: 4-dimethylaminophenol hydrochlorideCategories: 4-dimethylaminophenol, Compounds used in a research, industrial, or household setting
  9. Drug

    GsMtx-4

    go.drugbank.com/drugs/DB17861
    Investigational

    GsMtx-4 is a peptide found in tarantula venom that inhibits mechanosensitive ion channel (MSC) activity.

  10. Drug

    Avanafil

    go.drugbank.com/drugs/DB06237
    Approved

    Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. … In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively

    Categories: Drugs Used in Erectile Dysfunction, Cytochrome P-450 SubstratesSynonyms: (S)-4-(3-Chloro-4-methoxybenzylamino)-2-(2-hydroxymethylpyrrolidin-1-yl)-N-pyrimidin-2-ylmethyl-5-pyrimidinecarboxamide