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Mebrofenin
go.drugbank.com/drugs/DB15779ApprovedProducts: POLTECHMBRIDA 20 MG. KIT PARA LA PREPARACION RADIOFARMACEUTICANelarabine
go.drugbank.com/drugs/DB01280ApprovedInvestigational[A2331,AA2334,A2335] Results from 2 phase 2 studies on adult and pediatric T-ALL/T-LBL indicated that nelarabine can yield a 13% complete response (CR) rate in pediatric patients and 18% in adult patients … [A2332] Due to the rarity of these T-cell malignancies, nelarabine was first granted orphan drug status and a fast-track designation by the FDA to address the unmet therapeutic needs of these cancers.
Synonyms: 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purineProducts: NELARAMAX 250 MG/50 ML IV İNFÜZYONLUK ÇÖZELTİ , 1 ADET, NELARAMAX 250 MG/50 ML IV İNFÜZYONLUK ÇÖZELTİ , 6 ADETOmfiloctocog alfa
go.drugbank.com/drugs/DB19229InvestigationalOmfiloctocog alfa is under investigation in clinical trial NCT03947567 (Safety and Efficacy of Long-term Treatment With SCT800 in Previously Treated Hemophilia a Patients.).
Synonyms: ), THE B-DOMAIN N-AND C-TERMINAL FRAGMENTS (741-745), 1-740-BLOOD COAGULATION FACTOR VIII (RECOMBINANT HUMAN SCT800 HEAVY CHAIN) FUSION PROTEIN WITH HUMAN BLOOD COAGULATION FACTOR VIII B DOMAIN FRAGMENT (14-AMINO ACID LINKER) FUSION PROTEIN WITH BLOOD COAGULATIONRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnRofecoxib has a half-life of 17 hours and its mean oral bioavailability at therapeutically recommended doses of 125, 25, and 50 mg is approximately 93%. … Cytochrome P450 1A2, Cytochrome P450 3A4, Cytochrome P450 2C9, Cytochrome P450 2C8, and Prostaglandin G/H synthase 1 are known to metabolize rofecoxib.
Categories: Heterocyclic Compounds, 1-Ring, COX-2 InhibitorsSynonyms: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanoneBelimumab
go.drugbank.com/drugs/DB08879ApprovedInvestigationalIt is produced by recombinant DNA technology in a murine cell (NS0) expression system. … [L42630] Belimumab was first approved by the FDA on March 9, 2011,[A251495] making it the newest drug to be approved for the treatment of SLE in more than 50 years.
Categories: Decreased B Lymphocyte Activation, B Lymphocyte Stimulator-specific InhibitorProducts: BENLYSTA 200 MG / 1 ML, BENLYSTA SUBCUTÁNEO 200 MG / 1 MLDienogest
go.drugbank.com/drugs/DB09123ApprovedInvestigationalIt is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. … Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties.
Mixtures: ACOTOL EX, Velbienne 1 mg/2 mg FilmtablettenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAflibercept
go.drugbank.com/drugs/DB08885ApprovedInvestigationalgamma 1 (IgG1). … [A261276] It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa.
Products: EYLEA 40 MG/ML INTRAVITREAL ENJEKSIYON ICIN COZELTI ICEREN FLAKON, 1 ADET, ZALTRAP 200 MG/8 ML IV İNFÜZYONLUK KONSANTRE ÇÖZELTİ İÇEREN FLAKON, 1ADETMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalMethadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. … (due to a lack of active metabolites), minimal accumulation in renal failure, good bioavailability, low cost, and a long duration of action.
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersSynonyms: 6-Dimethylamino-4,4-diphenyl-3-heptanone, dl-MethadonePhentermine
go.drugbank.com/drugs/DB00191ApprovedIllicitInvestigationalPhentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug. … [A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 SubstratesProducts: PANBESY CAPSULE 15 MG, DUROMINE CAPSULE 15 mgDimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalIt is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … in response to oxidative stress.
Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: DIMETILFUMARATO EG, D-FUMARIC 240 CAPSULAS DE LIBERACIÓN RETARDADA 240 MG