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Displaying results 461 - 470 of 10000 in total
  1. Drug

    4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline

    go.drugbank.com/drugs/DB08580
    Experimental

    Synonyms: 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline
  2. Drug

    Tetracaine

    go.drugbank.com/drugs/DB09085
    ApprovedInvestigationalVet approved

    Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.

    Mixtures: Pliaglis 70 mg/g + 70 mg/g Creme, Pliaglis 70 mg/g + 70 mg/g creamSynonyms: 2-(dimethylamino)ethyl 4-(butylamino)benzoate, 2-(Dimethylamino)ethyl p-(butylamino)benzoate
  3. Drug

    Rofecoxib

    go.drugbank.com/drugs/DB00533
    ApprovedWithdrawn

    The proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2. … Rofecoxib has a half-life of 17 hours and its mean oral bioavailability at therapeutically recommended doses of 125, 25, and 50 mg is approximately 93%.

    Categories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Synonyms: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
  4. Drug

    Cangrelor

    go.drugbank.com/drugs/DB06441
    ApprovedInvestigational

    An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion therefore providing a rapid onset

    Categories: Heterocyclic Compounds, 2-Ring, Purinergic P2 Receptor AntagonistsSynonyms: [dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid
  5. Drug

    Olmesartan

    go.drugbank.com/drugs/DB00275
    ApprovedInvestigational

    Olmesartan is commonly used for the management of hypertension and Type 2 Diabetes-associated nephropathy, particularly in patients who are unable to tolerate ACE inhibitors. … ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis

    Mixtures: OLMETECANLO® 20 MG / 5 MG, ILTUXAM ® 20 MG - 10 MGCategories: Angiotensin 2 Receptor Blocker
  6. Drug

    Avutometinib

    go.drugbank.com/drugs/DB15254
    ApprovedInvestigational

    Avutometinib is a small molecule kinase inhibitor targeted against RAF/MEK1, key regulators of the RAS/RAF/MEK/ERK (MAPK) pathway. … [L53203,L53198] The MAPK pathway is implicated in variety of cancers, playing a key role in tumor cell proliferation, differentiation and survival.

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: N-(3-fluoro-4-((4-methyl-2-oxo-7-((pyrimidin-2-yl)oxy)-2H-1-benzopyran-3-yl)methyl)pyridin-2-yl)-N'-methylsulfuric diamide, Sulfamide, N-(3-fluoro-4-((4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl)methyl)-2-pyridinyl)-N'-methyl-
  7. Drug

    Uridine triacetate

    go.drugbank.com/drugs/DB09144
    Approved

    It reduces toxicity and cell-death associated with two cytotoxic intermediates: 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). … As a result of UMPS deficiency, patients experience a systemic deficiency of pyrimidine nucleotides, accounting for most symptoms of the disease.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2',3',5'-tri-O-acetyluridine, 2',3',5'-Triacetyluridine
  8. Drug

    Methyl salicylate

    go.drugbank.com/drugs/DB09543
    ApprovedInvestigationalVet approved

    It forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen. … It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments.

    Mixtures: KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 G, Muscle and Joint pain relief GR Isolate 750 mgCategories: Compounds used in a research, industrial, or household setting
  9. Drug

    Amisometradine

    go.drugbank.com/drugs/DB19368
    ApprovedWithdrawn

    Synonyms: 2,4(1h,3h)-pyrimidinedione, 6-amino-3-methyl-1-(2-methyl-2-propenyl)-, 6-amino-3-methyl-1-(2-methylallyl)-2,4(1h,3h)-pyrimidinedione
  10. Drug

    Biperiden

    go.drugbank.com/drugs/DB00810
    ApprovedInvestigationalWithdrawn

    A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol, alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanol