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Displaying results 4921 - 4930 of 10000 in total
  1. Drug

    Afamelanotide

    go.drugbank.com/drugs/DB04931
    Approved

    Afamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). … [L9092] Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.[L9122,L9125]

    Synonyms: MT-I, Melanotan 1Categories: Melanocortin 1 Receptor (MC1-R) Agonists, Compounds used in a research, industrial, or household setting
  2. Drug

    Eritoran

    go.drugbank.com/drugs/DB04933
    Investigational

    Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.

    Categories: Toll-Like Receptor 4, antagonists & inhibitors
  3. Drug

    Azimilide

    go.drugbank.com/drugs/DB04957
    Investigational

    It is not approved for use in any country, but is currently in clinical trials in the United States. … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels.

    Synonyms: 1-((5-(P-CHLOROPHENYL)FURFURYLIDENE)AMINO)-3-(4-(4-METHYL-1-PIPERAZINYL)BUTYL)HYDANTOIN, 2,4-IMIDAZOLIDINEDIONE, 1-(((5-(4-CHLOROPHENYL)-2-FURANYL)METHYLENE)AMINO)-3-(4-(4-METHYL-1-PIPERAZINYL)BUTYL)-Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  4. Drug

    Denufosol

    go.drugbank.com/drugs/DB04983
    Investigational

    A new drug application (NDA) was filed with the FDA in 2011, however, the second phase III clinical trial showed a lack of improvement in lung function for cystic fibrosis patients taking denufosol. … Denufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements in lung function during a phase III clinical trial.

    Categories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Migalastat

    go.drugbank.com/drugs/DB05018
    ApprovedInvestigational

    Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). … [L47036,L47057,L4274,L4278] In these patients, migalastat works by stabilizing the body’s dysfunctional alpha-Gal A enzyme so that it can clear the accumulation of glycosphingolipid disease substrate.

    Synonyms: (2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 1-DeoxygalactostatinCategories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones, Heterocyclic Compounds, 1-Ring
  6. Drug

    Elafibranor

    go.drugbank.com/drugs/DB05187
    ApprovedInvestigational

    Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist [A263833] that works to inhibit bile acid synthesis.

    Synonyms: PROPANOIC ACID, 2-(2,6-DIMETHYL-4-((1E)-3-(4-(METHYLTHIO)PHENYL)-3-OXO-1-PROPEN-1-YL)PHENOXY)-, PROPANOIC ACID, 2-(2,6-DIMETHYL-4-(3-(4-(METHYLTHIO)PHENYL)-3-OXO-1-PROPEN-1-YL)PHENOXY)-2-METHYL-Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  7. Drug

    Adenosine-5'-Monophosphate Glucopyranosyl-Monophosphate Ester

    go.drugbank.com/drugs/DB01774
    Experimental

    Serves as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants. [PubChem]

    Synonyms: Adenosine-5'-Monophosphate Glucopyranosyl-Monophosphate Ester
  8. Drug

    (Rp)-cAMPS

    go.drugbank.com/drugs/DB01790
    Experimental

    Synonyms: (Rp)-adenosine-3',5'-cyclic monophosphorothioate, adenosine-3',5'-cyclic monophosphorothioate, Rp-isomerCategories: Heterocyclic Compounds, 2-Ring
  9. Drug

    Piclamilast

    go.drugbank.com/drugs/DB01791
    Experimental

    Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. … It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma.

    Synonyms: 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamideCategories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 4 Inhibitors
  10. Drug

    Adenosine 3',5'-diphosphate

    go.drugbank.com/drugs/DB01812
    Experimental

    Synonyms: 3',5'-ADP, 3'-Phosphoadenosine 5'-phosphateCategories: Heterocyclic Compounds, 2-Ring