Piclamilast

DB01791ExperimentalSmall molecule

Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma.

Mechanism: Pharmacologically active on 3',5'-cyclic-AMP phosphodiesterase 4A, 3',5'-cyclic-AMP phosphodiesterase 4D, and 3',5'-cyclic-AMP phosphodiesterase 4B
Curator reviewed
Formula / weight: C₁₈H₁₈Cl₂N₂O₃ · 381.253 g/mol (avg)
Code names: RP 73-401

Resolves to

Compound

UNIIWM58D7C3ZTCAS144035-83-6ChEMBLCHEMBL42126ChEBI47619PubChem154575KEGGD05474

Structure

InChIKeyRRRUXBQSQLKHEL-UHFFFAOYSA-NSMILESCOC1=CC=C(C=C1OC1CCCC1)C(=O)NC1=C(Cl)C=NC=C1Cl

Targets

P27815PDE4AQ08499PDE4DQ07343PDE4BQ08493PDE4C

What you can answer from here — as of September 12, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Drug interactionStructured to mechanism, not free text

19+ReferencesStructured and connected to the statements they support

Which drugs share a target with Piclamilast, and which of those have an active Phase 3 trial?

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