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Displaying results 41 - 50 of 1193 in total
  1. Drug

    PA3-17

    go.drugbank.com/drugs/DB18569
    Investigational

    PA3-17 is CD7-directed chimeric antigen receptor (CAR) T-cell therapy.

    Synonyms: Chimeric Antigen Receptor T Cells targeting CD7
  2. Drug

    OriCar-017

    go.drugbank.com/drugs/DB17280
    Investigational

    Synonyms: chimeric antigen receptor (CAR)-T cell therapy targeting G protein-coupled receptor class-C group-5 member-D (GPRC5D)
  3. Drug

    MP-0250

    go.drugbank.com/drugs/DB17218
    Investigational

    Synonyms: Designed ankyrin repeat protein (MP0250)
  4. Drug

    Veligrotug

    go.drugbank.com/drugs/DB18976
    ApprovedInvestigational

    Veligrotug is a humanized IgG1 monoclonal antibody that binds the insulin-like growth factor-1 receptor and blocks ligand-induced receptor autophosphorylation, interrupting IGF-1R signaling.

    Categories: Insulin-like Growth Factor-1 Receptor InhibitorSynonyms: Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human-Mus musculus monoclonal VRDN-001 γ1-chain), disulfide with human-Mus musculus monoclonal VRDN-001 κ-chain, dimer, Immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin-like growth factor 1 receptor, IGF1-R, IGF-1R, CD221)], chimeric monoclonal antibody (gamma1 heavy chain chimeric (1-454) [VH (Mus musculus IGHV1S81
  5. Drug

    PMC-403

    go.drugbank.com/drugs/DB18132
    Investigational

    PMC-403 is a novel Tie2-activating antibody being investigated for the treatment of systemic capillary leak syndrome.

    Synonyms: a fully human monoclonal antibody that binds and activates the Tie2 receptor
  6. Drug

    ALLO-715

    go.drugbank.com/drugs/DB18640
    Investigational

    ALLO-715 is an allogeneic chimeric antigen receptor T Cell therapy targeting B cell maturation antigen (BCMA).

    Synonyms: Allogenic Chimeric Antigen Receptor T Cells Targeting B Cell Maturation Antigen (BCMA)
  7. Target

    Lethal factor

    go.drugbank.com/bio_entities/BE0001363
    TargetBacillus anthracis

    LF is not toxic by itself and only acts as a lethal factor when associated with protective antigen (PA) to form the lethal toxin (LeTx): PA is required for LF translocation into the host cytosol (PubMed … Lethal factor (LF), which constitutes one of the three proteins composing the anthrax toxin, is able to trigger rapid cell death in macrophages (PubMed:10475971, PubMed:11104681, PubMed:3711080, PubMed

    Polypeptides: Lethal factorSynonyms: Anthrax lethal toxin endopeptidase component
  8. Drug

    AD-114

    go.drugbank.com/drugs/DB18285
    Experimental

    Synonyms: Human single domain antibody-like protein inhibitor of the chemokine receptor type 4
  9. Drug

    Losartan

    go.drugbank.com/drugs/DB00678
    ApprovedInvestigational

    Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension.

    Categories: Angiotensin 2 Receptor Blocker, Angiotensin II receptor antagonistsProducts: RECEP-H
  10. Drug

    AVID-200

    go.drugbank.com/drugs/DB18454
    Investigational

    AVID-200 is an Anti-transforming growth factor beta (TGF-β) trap fusion protein.

    Synonyms: Tgfbeta receptor ectodomain-igg fc fusion protein avid200, Tgf-.beta. ligand trap comprised of tgf-.beta. receptor ectodomains fused to a human fc domain (avid-200)