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Midomafetamine
go.drugbank.com/drugs/DB01454IllicitInvestigationalAn N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. … It is commonly referred to as MDMA or ecstasy. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems.
Eniluracil
go.drugbank.com/drugs/DB03516Investigationals most widely-used oncology agents. 5-FU is widely used in the U.S. and is often first or second line therapy for a variety of cancers including colorectal, breast, gastric, head and neck, ovarian and … Eniluracil could improve 5-FU by increasing its effectiveness, reducing its side effects and/or making it orally available.
Temanogrel
go.drugbank.com/drugs/DB05227InvestigationalAPD791 is an oral anti-thrombotic drug candidate being evaluated in a Phase 1 clinical trial by Arena. … APD791 is intended to lower the risk of arterial thrombosis by reducing the amplification of platelet aggregation, arterial constriction and intimal hyperplasia mediated by serotonin.
Tandamine
go.drugbank.com/drugs/DB09192ExperimentalTandamine was researched in 1970s as an antidepressant but was never commercialized. Tandamine is an analog of pirandamine and it acts as a selective serotonin reuptake inhibitor (SSRI).
Ruplizumab
go.drugbank.com/drugs/DB06475InvestigationalRuplizumab is a humanized monoclonal antibody used as an immunosuppressive drug and is a component of Antova.
Categories: Amino Acids, Peptides, and ProteinsCaprylic acid
go.drugbank.com/drugs/DB04519ApprovedInvestigationalWithdrawnCaprylic acid is an eight-carbon chain fatty acid, also known systematically as octanoic acid. It is found naturally in coconuts and breast milk. … It is an oily liquid with a slightly unpleasant rancid-like smell that is minimally soluble in water.
Synonyms: n-Octoic acid, n-octylic acidLazuvapagon
go.drugbank.com/drugs/DB19046InvestigationalLazuvapagon is under investigation in clinical trial NCT03116191 (Trial of SK-1404 for Nocturia Due to Nocturnal Polyuria in Japanese Subjects).
Synonyms: (4s)-n-((2s)-1-hydroxypropan-2-yl)-methyl-1-(2-methyl-4-(3-methyl-1h-pyrazol-1-yl)benzoyl)-2,3,4,5-tetrahydro-1h-1-benzazepine-4-carboxamide, 1h-1-benzazepine-4-carboxamide, 2,3,4,5-tetrahydro-n-((1s)-2-hydroxy-1-methylethyl)-4-methyl-1-(2-methyl-4-(3-methyl-1h-pyrazol-1-yl)benzoyl)-, (4s)-Saprisartan
go.drugbank.com/drugs/DB01347ExperimentalSaprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. … It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism [A14009].
Categories: Angiotensin II receptor antagonists, Angiotensin II Type 1 Receptor BlockersOlmutinib
go.drugbank.com/drugs/DB13164InvestigationalIt is available under the brand name Olita made by Hanmi Pharmaceuticals [A19196]. Olmutinib was developed by Hanmi Pharmaceuticals and Boehringer Ingelheim. … Olmutinib is an orally active epidermal growth factor receptor inhibitor used in the treatment of T790M mutation positive non-small cell lung cancer.
Categories: Antineoplastic and Immunomodulating AgentsS-8510
go.drugbank.com/drugs/DB06504ExperimentalS-8510 / SB-737552 is a BZD inverse agonist investigated for the treatment of Alzheimer’s disease and mild to moderate senile dementia. It was being codeveloped by Shionogi and GlaxoSmithKline.