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Ezatiostat
go.drugbank.com/drugs/DB05460InvestigationalThis compound belongs to the peptides. … These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen
St. John's Wort
go.drugbank.com/drugs/DB01323ApprovedNutraceuticalCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeIsoetharine
go.drugbank.com/drugs/DB00221ApprovedIsoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. Isoetharine is a fast-acting bronchodilator used for emphysema, bronchitis and asthma.
Categories: Adrenergic beta-2 Receptor AgonistsRUS 3108
go.drugbank.com/drugs/DB05911ExperimentalThe drug’s Phase I clinical trials have been initiated in Europe to assess safety of the drug compound in healthy volunteers. … RUS 3108 is being developed for the treatment of atherosclerosis, the major cause of cardiovascular disorders such as heart attacks and stroke by Dr. Reddy’s Laboratories.
Oregovomab
go.drugbank.com/drugs/DB04964InvestigationalOregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Tipifarnib
go.drugbank.com/drugs/DB04960InvestigationalIt belongs to the family of drugs called farnesyltransferase inhibitors. It is also called Zarnestra. In June 2005, the FDA issued a Not Approvable Letter for Zarnestra. … Tipifarnib (R-115777) is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer.
Dimethyltryptamine
go.drugbank.com/drugs/DB01488IllicitInvestigationalAn N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of seroton...
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin Receptor AgonistsButyrfentanyl
go.drugbank.com/drugs/DB09173ExperimentalIllicit[L7814] The DEA in the United States has confirmed at least 40 fatalities involving butyrfentanyl before May 2016.[L7811] … Butyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug.
PW2101
go.drugbank.com/drugs/DB06483ExperimentalThe drug was developed by Penwest Pharmaceuticals and in 2005 the FDA issues a Non-Approval letter due to the degree of kinetic variability of PW2101 observed among individuals. … The development of PW2101 has since been discontinued.
AZD3409
go.drugbank.com/drugs/DB04893ExperimentalAs of February 2007 the development of AZD3409 had been discontinued. … AZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. Phase I trials were initiated January 2003, and were ongoing as of February 2004.