Identification
- Summary
St. John's Wort is an herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety.
- Generic Name
- St. John's Wort
- DrugBank Accession Number
- DB01323
- Background
Not Available
- Type
- Biotech
- Groups
- Approved, Investigational, Nutraceutical
- Synonyms
- Common st johnswort flowering top
- Common st. john's wort flowering top
- Common st. john's wort herb
- Common st. johnswort flowering top
- Guanyejinsitao
- Hyperici herba
- Hypericum nachitschevanicum flowering top
- Hypericum perforatum flowering top
- Hypoxis hemerocallidea root extract
- Klamath weed flowering top
- Klamathweed flowering top
- Saint johns wort
- St john's wort
- St Johns Wort
- St. john’s wort
- St. johns wort
- St. johnswort flowering top
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The metabolism of 1,2-Benzodiazepine can be increased when combined with St. John's Wort. Abametapir The serum concentration of St. John's Wort can be increased when it is combined with Abametapir. Abatacept The metabolism of St. John's Wort can be increased when combined with Abatacept. Abemaciclib The serum concentration of Abemaciclib can be decreased when it is combined with St. John's Wort. Abiraterone The metabolism of Abiraterone can be increased when combined with St. John's Wort. Abrocitinib The metabolism of Abrocitinib can be decreased when combined with St. John's Wort. Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with St. John's Wort. Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with St. John's Wort. Acebutolol The metabolism of Acebutolol can be decreased when combined with St. John's Wort. Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with St. John's Wort. 
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- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Ethical Herbals ST. John's Wort Tablet 300 mg/1 Oral Ashbury Research Corporation Not applicable Not applicable Canada 
Ethical Herbals ST. John's Wort Tablet 150 mg/1 Oral Ashbury Research Corporation Not applicable Not applicable Canada Felis Forte Capsules 425mg Capsule 425 mg / cap Oral Rhoxalpharma Inc Not applicable Not applicable Canada Felis Tablets 250mg Tablet 250 mg / tab Oral Rhoxalpharma Inc Not applicable Not applicable Canada ST. John's Wort Capsule 300 mg / cap Oral New Vision Nutritionals Company 1998-10-01 2002-11-20 Canada ST. John's Wort Capsule 300 mg Oral Swiss Herbal Remedies Ltd. 1998-02-20 2008-08-15 Canada ST. John's Wort Capsule 300 mg Oral Wampole Brands 2003-02-01 2004-06-29 Canada ST. John's Wort Capsule 1500 mg Oral Sisu Inc. 1998-02-11 2007-07-20 Canada ST. John's Wort Capsule 1500 mg / cap Oral Bioprint Laboratories Ltd 2000-06-08 2001-07-31 Canada ST. John's Wort Capsule 1050 mg Oral Wn Pharmaceuticals Ltd. 1998-12-15 2006-08-08 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dynamiclear Rapid St. John's Wort (0.5 mg/1mL) + Calendula officinalis flower (0.5 mg/1mL) + Cupric sulfate pentahydrate (40 mg/1mL) Liquid Topical RX PHARMA-PACK, INC. 2019-02-06 2022-12-31 US 
Dynamiclear Rapid St. John's Wort (0.5 mg/1mL) + Calendula officinalis flower (0.5 mg/1mL) + Cupric sulfate pentahydrate (40 mg/1mL) Liquid Topical RX PHARMA-PACK, INC. 2019-02-06 2022-12-31 US Nite-caps St. John's Wort (20 mg / cap) + Hops (40 mg / cap) + Valerian (40 mg / cap) Capsule Oral Flora Manufacturing And Distributing Ltd. 1991-12-31 2002-09-10 Canada S. R. Formula St. John's Wort (200 mg / mL) + Valerian (133.2 mg / mL) Liquid Oral Morinda Canada 2002-01-14 2006-07-12 Canada
Categories
- ATC Codes
- N06AX25 — Hyperici herba
- Drug Categories
- Angiosperms
- Antidepressive Agents
- Antidepressive Agents Indicated for Depression
- Biological Products
- Central Nervous System Depressants
- Clusiaceae
- Complex Mixtures
- Cytochrome P-450 CYP2C19 Inducers
- Cytochrome P-450 CYP2C19 Inducers (strength unknown)
- Cytochrome P-450 CYP2C19 Substrates
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP2D6 Inhibitors (weak)
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 CYP3A Inducers (strong)
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Inducers
- Cytochrome P-450 CYP3A4 Inducers (strong)
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 CYP3A4 Substrates (strength unknown)
- Cytochrome P-450 Enzyme Inducers
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Substrates
- Embryophyta
- Eukaryota
- Herbs and Natural Products
- Hyperglycemia-Associated Agents
- Nervous System
- P-glycoprotein inducers
- Pharmaceutical Preparations
- Plant Preparations
- Psychoanaleptics
- Rosanae
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Streptophyta
- Tracheophyta
- Viridiplantae
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- UFH8805FKA
- CAS number
- 84082-80-4
References
- Synthesis Reference
Trevor Percival Castor, Theodore Abraham Tyler, Richard Joseph Student, "Methods for making Hypericum fractions and St. John's Wort products." U.S. Patent US6291241, issued December, 1998.
US6291241- General References
- Lecrubier Y, Clerc G, Didi R, Kieser M: Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am J Psychiatry. 2002 Aug;159(8):1361-6. [Article]
- Randlov C, Mehlsen J, Thomsen CF, Hedman C, von Fircks H, Winther K: The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia--a double-blind placebo-controlled study. Phytomedicine. 2006 Mar;13(4):215-21. Epub 2006 Jan 19. [Article]
- Authors unspecified: Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial. JAMA. 2002 Apr 10;287(14):1807-14. [Article]
- External Links
- PubChem Substance
- 46507869
- 1310069
- PharmGKB
- PA164924486
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Hypericum_perforatum
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Diagnostic Pain 1 4 Completed Treatment Healthy Adults / Nootropic Potential of Hypericum and Alprazolam / Subclinical Anxious Adults 1 4 Completed Treatment Healthy Subjects (HS) 1 3 Completed Treatment Atypical Depression 1 3 Completed Treatment Raynaud's Phenomenon 1 3 Terminated Treatment Pain 1 3 Unknown Status Diagnostic Peritoneal Carcinomatosis 1 3 Withdrawn Treatment Adult Solid Tumor / Breast Cancer / Head And Neck Cancer / Kidney and Urinary Cancer / Male Reproductive Cancer / Thorax and Respiratory Cancer 1 2 Completed Treatment Anxiety Disorders / Major Depressive Disorder (MDD) 1 2 Completed Treatment Attention Deficit Hyperactivity Disorder (ADHD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Guna Inc.
- Pekana Naturheilmittel GmbH
- Weleda Inc.
- Dosage Forms
Form Route Strength Liquid Topical Tablet Oral 900 mg / tab Tablet Oral 150 mg/1 Tablet Oral 300 mg/1 Tablet Oral 300 mg Capsule Oral 425 mg / cap Tablet Oral 250 mg / tab Tablet Oral 180 mg / tab Tablet Oral 300 mg / tab Capsule Oral Tablet Oral 1500 mg / tab Tablet, coated Liquid Oral Capsule Oral 1050 mg Capsule Oral 1500 mg / cap Capsule Oral 1500 mg Capsule Oral 300 mg / cap Capsule Oral 750 mg / cap Tablet Oral 500 mg Liquid Oral 1000 mg / mL Capsule Oral 1045 mg / cap Capsule Oral 1320 mg / cap Liquid Oral 1 g / 1 mL Capsule Oral 300 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- SubstrateInducerActivator
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Wenk M, Todesco L, Krahenbuhl S: Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. Br J Clin Pharmacol. 2004 Apr;57(4):495-9. [Article]
- Hokkanen J, Tolonen A, Mattila S, Turpeinen M: Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. Eur J Pharm Sci. 2011 Feb 14;42(3):273-84. doi: 10.1016/j.ejps.2010.12.002. Epub 2010 Dec 17. [Article]
- Klotz U: Interaction potential of lercanidipine, a new vasoselective dihydropyridine calcium antagonist. Arzneimittelforschung. 2002;52(3):155-61. doi: 10.1055/s-0031-1299873. [Article]
- FDA Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Inhibitor
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
- Gene Name
- CYP2D6
- Uniprot ID
- P10635
- Uniprot Name
- Cytochrome P450 2D6
- Molecular Weight
- 55768.94 Da
References
- Hokkanen J, Tolonen A, Mattila S, Turpeinen M: Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. Eur J Pharm Sci. 2011 Feb 14;42(3):273-84. doi: 10.1016/j.ejps.2010.12.002. Epub 2010 Dec 17. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- SubstrateInducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
- Gene Name
- CYP2C19
- Uniprot ID
- P33261
- Uniprot Name
- Cytochrome P450 2C19
- Molecular Weight
- 55930.545 Da
References
- Hokkanen J, Tolonen A, Mattila S, Turpeinen M: Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. Eur J Pharm Sci. 2011 Feb 14;42(3):273-84. doi: 10.1016/j.ejps.2010.12.002. Epub 2010 Dec 17. [Article]
- Rahimi R, Abdollahi M: An update on the ability of St. John's wort to affect the metabolism of other drugs. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):691-708. doi: 10.1517/17425255.2012.680886. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Xenobiotic-transporting atpase activity
- Specific Function
- Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Gene Name
- ABCB1
- Uniprot ID
- P08183
- Uniprot Name
- Multidrug resistance protein 1
- Molecular Weight
- 141477.255 Da
References
- Durr D, Stieger B, Kullak-Ublick GA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K: St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther. 2000 Dec;68(6):598-604. [Article]
Drug created at June 30, 2007 17:20 / Updated at February 08, 2023 20:46