St. John's Wort

DB01323ApprovedNutraceuticalAntidepressive Agents Indicated for Depression

St. John's Wort is an herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety.

First approval
Canada, 1997
Also known as
Common st johnswort flowering top · Common st. john's wort flowering top · Common st. john's wort herb · Common st. johnswort flowering top · Guanyejinsitao

Resolves to

Compound
UNIIUFH8805FKACAS84082-80-4
Clinical / RWD
RxNorm1310069ATCN06AX25PharmGKBPA164924486
Targets
P23975SLC6A2
Transporters
P08183ABCB1

What you can answer from here — as of September 20, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1TransporterSubstrate / inhibitor direction, not just membership
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1,544Drug interactionsStructured to mechanism, not free text
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27Clinical trialsPhase, status and sponsor resolved per trial
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11Structured indicationsCondition, population, route and combination as fields, not prose
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39Marketed productsAcross 4 countries and 24 labellers
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1ATC codeIncluding every combination product, plus 36 drug categories
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12+ReferencesStructured and connected to the statements they support
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