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SO-101
go.drugbank.com/drugs/DB05345ExperimentalDoxepin has been prescribed for more than 40 years for the treatment of depression and anxiety at dosages typically ranging from 75 mg to 300 mg per day. … SO-101(Silenor) is a low-dose oral tablet formulation of doxepin hydrochloride that is patent protected for its use in insomnia.
Pradefovir mesylate
go.drugbank.com/drugs/DB05478InvestigationalAs adefovir is poorly absorbed and associated with a high level of nephrotoxicity, pradefovir mesilate was designed to specifically target the liver and reduce risks to external tissue, especially the … [Adefovir] (Hepsera) is an acyclic phosphonate analogue of adenine that is used to treat hepatitis B virus.
Categories: Heterocyclic Compounds, 2-RingInternational brands: Hepavir BElacytarabine
go.drugbank.com/drugs/DB05494InvestigationalElacytarabine is a patented new chemical entity of the nucleoside analog class, with improved biological properties and the potential to treat solid tumours such as non-small cell lung cancer, malignant … Elacytarabine is a fatty acid derivative of [cytarabine], an approved cytotoxic cancer drug. Cytarabine has limitations such as minimal uptake in solid tumours and is only used to treat leukaemia.
Categories: Heterocyclic Compounds, 1-RingEVT 201
go.drugbank.com/drugs/DB05721InvestigationalEVT 201 is a novel partial positive allosteric modulator of the GABAA receptor complex which is being developed as a treatment for insomnia. It is being developed by Evotec Inc.
Categories: Heterocyclic Compounds, 2-RingInosinic Acid
go.drugbank.com/drugs/DB04566InvestigationalInosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Categories: Heterocyclic Compounds, 2-RingQXL138AM
go.drugbank.com/drugs/DB18552InvestigationalQXL138AM is a masked immunocytokine (MIC) comprised of an anti-CD138 immunoglobulin G1 antibody fused to interferon alpha 2a. It binds the CD138 protein on the surface of the tumour cells.
Synonyms: Masked immunocytokine (MIC) comprised of an anti-CD138 immunoglobulin G1 antibody fused to interferon alpha 2aAlizapride
go.drugbank.com/drugs/DB01425InvestigationalAlizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. … This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, including that which may occur postoperatively.
Categories: Heterocyclic Compounds, 1-RingProducts: ALIPRID ®, PLITICAN® GOTASFamprofazone
go.drugbank.com/drugs/DB16702Experimental[L34724] It is important to note that the drug is metabolized to [methamphetamine] and [amphetamine] in the body and can lead to positive tests results for illicit drug use. … [A236369,L34724] Famprofazone is included in the list of prohibited substances specified by the ‘World Anti-Doping Agency’ (WADA).[L34729]
Categories: Heterocyclic Compounds, 1-RingARCoV
go.drugbank.com/drugs/DB15855ExperimentalAs of July 2020, the vaccine candidate is set for Phase 1 clinical trials to investigate for safety, tolerance, and immunogenicity (ChiCTR2000034112). … It is the first COVID-19 mRNA vaccine to be approved for clinical trials in China, and was co-developed by Abogen Biosciences, Walvax Biotechnolgoy Co., Ltd. and the People’s Liberation Army (PLA) Academy
BacTRL-spike
go.drugbank.com/drugs/DB15811InvestigationalAs of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled Trial (NCT04334980) to test the safety and immunogenicity of the vaccine. … BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids.