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Corticosterone
go.drugbank.com/drugs/DB04652InvestigationalAn adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. … (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 11beta,21-Dihydroxy-4-pregnene-3,20-dione, (11β)-11,21-dihydroxypregn-4-ene-3,20-dione1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
go.drugbank.com/drugs/DB08742ExperimentalSynonyms: 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine
go.drugbank.com/drugs/DB08531ExperimentalSynonyms: 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amineVeverimer
go.drugbank.com/drugs/DB18977InvestigationalVeverimer is under investigation in clinical trial NCT03390842 (Long-term Safety Extension to Study TRCA-301).
Synonyms: 1,3-propanediamine, n1,n3-di-2-propen-1-yl-, polymer with 1,2-dichloroethane and 2-propen-1-amine, N1,n3-bis(prop-2-en-1-yl)propan-1,3-diamine copolymer with 1,2-dichloroethane and prop-2-en-1-aminePralurbactam
go.drugbank.com/drugs/DB19437InvestigationalPralurbactam is under investigation in clinical trial NCT06633718 (Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in CIAI).
Synonyms: 1R,2S,5R)-2-{[2-(guanidinooxy)ethoxy]carbamoyl}-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate, (1R,2S,5R)-2-[[[2-[[(Aminoiminomethyl)amino]oxy]ethoxy]amino]carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl hydrogen sulfateTacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalThis FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription. … It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide.
Mixtures: Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1%, Niacinamide 4% / Tacrolimus 0.1%Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexMecbotamab vedotin
go.drugbank.com/drugs/DB17442InvestigationalMecbotamab vedotin is an anti-Axl humanized monoclonal antibody conjugated to monomethyl auristatin E using a cleavable linker (CAB-Axl-ADC).[A255212]
Synonyms: -CHAIN, DIMER, THIOETHER WITH N-(((4-((N-(6-(3-MERCAPTO-2,5-DIOXO, IMMUNOGLOBULIN G1 (DE-450-LYSINE), ANTI-(HUMAN TYROSINE KINASE RECEPTOR AXL) (HUMAN-MUS MUSCULUS MONOCLONAL BA301 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL BA301 .KAPPA.Monophosphoryl lipid A
go.drugbank.com/drugs/DB19290InvestigationalSynonyms: 3-O-DESACYL-4′-MONOPHOSPHORYL LIPID A FREE ACID, AS01E COMPONENT MPL-ABecaplermin
go.drugbank.com/drugs/DB00102ApprovedInvestigationalBecaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds. … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae.
Categories: Proto-Oncogene Proteins c-sisSynonyms: PDGF-21-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid
go.drugbank.com/drugs/DB08355ExperimentalSynonyms: 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid