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Displaying results 541 - 550 of 10000 in total
  1. Drug

    Mequinol

    go.drugbank.com/drugs/DB09516
    ApprovedWithdrawn

    Mequinol is a phenol used in various applications. … It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture

    Synonyms: 4-MethoxyphenolCategories: Compounds used in a research, industrial, or household setting
  2. Drug

    4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose

    go.drugbank.com/drugs/DB03495
    Experimental

    Synonyms: 4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose
  3. Drug

    Bumetanide

    go.drugbank.com/drugs/DB00887
    ApprovedInvestigational

    Bumetanide is a sulfamyl diuretic.

    Mixtures: BURINEX TABLET 1 mg, BURINEX TABLET 1 mgCategories: Increased Diuresis at Loop of Henle
  4. Drug

    Vismodegib

    go.drugbank.com/drugs/DB08828
    ApprovedInvestigational

    [A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. … The Hedgehog signaling pathway plays an important role in the development of organs and tissues during embryogenesis.

    Synonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  5. Drug

    Midostaurin

    go.drugbank.com/drugs/DB06595
    ApprovedInvestigational

    Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. … It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108].

    Synonyms: 4'-N-benzoylstaurosporineCategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Inducers
  6. Drug

    Flavone

    go.drugbank.com/drugs/DB07776
    ApprovedInvestigational

    Synonyms: 2-phenyl-4H-1-benzopyran-4-one, 2-Phenyl-4-chromoneCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  7. Drug

    H3B-8800

    go.drugbank.com/drugs/DB14017
    Investigational

    H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine [L2551]. … H3B-8800 was granted orphan drug status by the FDA in August 2017 and is in clinical trials for the treatment of acute myelogenous leukemia and chronic myelomonocytic leukemia [L2551].

    Categories: Heterocyclic Compounds, 1-RingSynonyms: (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate, (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-Dimethyl-12-Oxo-2-[(2E,4E,6R)-6-(Pyridin-2-Yl)Hepta-2,4-Dien-2-Yl]Oxacyclododec-4-En-6-Yl 4-Methylpiperazine-1-Carboxylate
  8. Drug

    Ropsacitinib

    go.drugbank.com/drugs/DB18709
    Investigational

    Synonyms: Cyclobutaneacetonitrile, 3-cyano-1-(4-(6-(1-methyl-1h-pyrazol-4- yl)pyrazolo(1,5-a)pyrazin-4-yl)-1h-pyrazol-1-yl)-, trans-, Trans-3-cyano-1-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrazolo(1,5-a)pyrazin-4-yl)- 1h-pyrazol-1-yl)-cyclobutaneacetonitrileCategories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Fexofenadine

    go.drugbank.com/drugs/DB00950
    ApprovedInvestigational

    [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity. … [L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation

    Mixtures: ALERMED® D, FEXU D® SUSPENSIONCategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-Ring
  10. Drug

    Thiabendazole

    go.drugbank.com/drugs/DB00730
    ApprovedVet approvedWithdrawn

    2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 2-(thiazol-4-yl)benzimidazole, 4-(2-benzimidazolyl)thiazole